Evidence map›Paper›PMID 33416454›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.

Vidhi Dhagia, Atsushi Kitagawa, Christina Jacob, Connie Zheng, Angelo D'Alessandro, John G Edwards, Petra Rocic, Rakhee Gupte, Sachin A Gupte

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vidhi DhagiaDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Atsushi KitagawaDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Christina JacobDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Connie ZhengDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
John G EdwardsDepartment of Physiology, New York Medical College, Valhalla, New York.
Petra RocicDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Rakhee GupteRaadysan Biotech., Incorporated, Fishkill, New York.
Sachin A GupteDepartment of Pharmacology, New York Medical College, Valhalla, New York.
New York Medical College · USUniversity of Colorado Anschutz Medical Campus · US

Funding

The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9M
The role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4M
Interactions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6M
Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL132574 · NHLBI · NEW YORK MEDICAL COLLEGE · PI GUPTE, SACHIN A, MIANO, JOSEPH M · 2017 to 2020
$2.5M
MIRAGES: Metabolic Investigation of Red blood cells as a function of Aging, Genetics, Environment, and StorageR21HL150032 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2021
$414k
NHLBI NIH HHS R01 HL132574NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R21 HL150032NHLBI NIH HHS RO1HL132574
6 · The paper itself

Abstract

We aimed to determine

Indexed as

Protein Processing, Post-TranslationalAcetylationAnimalsCell LineDisease Models, AnimalFemaleGene Expression RegulationGlucosephosphate DehydrogenaseHemodynamicsHistonesHumansMaleMetabolic SyndromeMice, TransgenicMuscle, Smooth, VascularMutationGlucosephosphate DehydrogenaseHistonesMYH11 protein, humanMyh11 protein, ratMyocardinmyosin 11, mouseMyosin Heavy ChainsNuclear ProteinsSerum Response Factorserum response factor, ratSRF protein, humanSrf protein, mouseTrans-ActivatorsTranscription FactorsG6PDMediterranean variantmetabolic syndromePPPsmooth muscle cell phenotype

Identifiers

PMID33416454
PMCPMC7988761
OpenAlexW3120154577

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.