Evidence map›Paper›PMID 33422769›Full record

ArticleCell calcium2021

Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice.

Hannah L West, Kathryn L Corbin, Cathleen V D'Angelo, Lauren M Donovan, Ishrat Jahan, Guoqiang Gu, Craig S Nunemaker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. The MODY-associatedeLife · 2024
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hannah L WestHonors Tutorial College, Ohio University, Athens, OH, USA; Dept. of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Kathryn L CorbinDept. of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Cathleen V D'AngeloDept. of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Lauren M DonovanDept. of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Ishrat JahanDept. of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
Guoqiang GuDept. of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Program in Developmental Biology and Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Craig S NunemakerDept. of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA. Electronic address: nunemake@ohio.edu.
Ohio University · USVanderbilt University · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
The Mechanisms of Islet Cell Specification and DifferentiationR01DK065949 · NIDDK · VANDERBILT UNIVERSITY · PI GU, GUOQIANG · 2004 to 2017
$4.4M
The DNA methylome-based regulation of functional beta-cell massR01DK125696 · NIDDK · VANDERBILT UNIVERSITY · PI Guoqiang Gu · 2020 to 2026
$3.4M
Regulating stress response to promote postnatal beta-cell function and survivalR01DK128710 · NIDDK · VANDERBILT UNIVERSITY · PI GU, GUOQIANG · 2021 to 2024
$1.9M
PANCREATIC FATE DETERMINATION AND STEM CELL CULTUREF32DK009832 · NIDDK · HARVARD UNIVERSITY · PI GU, GUOQIANG · 1998 to 2001
$74k
NIDDK NIH HHS F32 DK009832NIDDK NIH HHS R01 DK065949NIDDK NIH HHS R01 DK125696NIDDK NIH HHS R01 DK128710NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

Pancreatic islet cells develop mature physiological responses to glucose and other fuels postnatally. In this study, we used fluorescence imaging techniques to measure changes in intracellular calcium ([Ca

Indexed as

Calcium SignalingAgingAnimalsAnimals, NewbornCalciumCalcium Channels, L-TypeDiabetes MellitusEndoplasmic ReticulumGene Expression RegulationGlucoseGlycolysisHomeostasisIslets of LangerhansMiceNifedipinePotassium ChlorideCalciumCalcium Channels, L-TypeGlucoseNifedipinePotassium ChlorideCalciumCalcium signalingDevelopmentDiabetesEndoplasmic reticulumFPKMGlucoseIon channelsIsletMaturationNeonatalPostnatalRNA sequencingβ Cell

Identifiers

PMID33422769
PMCPMC8785357
OpenAlexW3114870523

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.