Evidence map›Paper›PMID 33423527›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin.

Julian M Stewart, Irfan A Warsy, Paul Visintainer, Courtney Terilli, Marvin S Medow

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Pooled it
  2. Repurposing of NKA inhibitors ('cardiac glycosides'): a critical analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
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  5. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Julian M StewartFrom the Department of Pediatrics (J.M.S., I.A.W., C.T., M.S.M.), New York Medical College, Valhalla.
Irfan A WarsyFrom the Department of Pediatrics (J.M.S., I.A.W., C.T., M.S.M.), New York Medical College, Valhalla.
Paul VisintainerBaystate Medical Center, University of Massachusetts School of Medicine, Worcester (P.V.).
Courtney TerilliFrom the Department of Pediatrics (J.M.S., I.A.W., C.T., M.S.M.), New York Medical College, Valhalla.
Marvin S MedowFrom the Department of Pediatrics (J.M.S., I.A.W., C.T., M.S.M.), New York Medical College, Valhalla.

Funding

Cardiovagal baroreflex deficits impair neurovascular coupling and cognition in Postural Tachycardia SyndromeR01HL134674 · NHLBI · NEW YORK MEDICAL COLLEGE · PI STEWART, JULIAN M · 2017 to 2020
$2.5M
Mechanisms of Vasovagal SyncopeR01HL112736 · NHLBI · NEW YORK MEDICAL COLLEGE · PI STEWART, JULIAN M · 2013 to 2016
$2.1M
NHLBI NIH HHS R01 HL112736NHLBI NIH HHS R01 HL134674
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Postural Orthostatic Tachycardia SyndromeAdultBaroreflexBlood PressureCardiotonic AgentsCholinesterase InhibitorsDigoxinDizzinessFemaleHeart RateHumansHypovolemiaOutcome Assessment, Health CarePatient PositioningPyridostigmine BromideSympathetic Nervous SystemCardiotonic AgentsCholinesterase InhibitorsDigoxinPyridostigmine Bromidebaroreflexdigoxinmodified oxford methodorthostasispostural tachycardia syndromepyridostigmine

Identifiers

PMID33423527
PMCPMC7946724

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.