Evidence mapPaperPMID 33425976Full record

ReviewFrontiers in nutrition2020

Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota.

Elvira Verduci, Chiara Mameli, Matilde Amatruda, Agnese Petitti, Sara Vizzuso, Farah El Assadi, Gianvincenzo Zuccotti, Shaikha Alabduljabbar, Annalisa Terranegra

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  7. Beneficial health effects of ultraviolet radiation: expert review and conference report.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
  8. Review
  9. Effects of Free or ImmobilizedMicroorganisms · 2024
    Article
  10. Article
  11. Review
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Elvira VerduciDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Chiara MameliDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Matilde AmatrudaDepartment of Health Sciences, University of Milan, Milan, Italy.
Agnese PetittiDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Sara VizzusoDepartment of Health Sciences, University of Milan, Milan, Italy.
Farah El AssadiCollege of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
Gianvincenzo ZuccottiDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.
Shaikha AlabduljabbarResearch Department, Sidra Medicine, Doha, Qatar.
Annalisa TerranegraResearch Department, Sidra Medicine, Doha, Qatar.
University of Milan · ITHamad bin Khalifa University · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes (T1D) appears most frequently in childhood, with an alarming increasing incidence in the last decades. Although the genetic predisposition is a major risk factor, it cannot solely explain the complex etiology of T1D which is still not fully understood. In this paper, we reviewed the most recent findings on the role of early nutrition and the involvement of the gut microbiota in the etiopathogenesis of T1D. The main conclusions that are withdrawn from the current literature regarding alleviating the risk of developing T1D through nutrition are the encouragement of long-term breast-feeding for at least the first 6 months of life and the avoidance of early complementary foods and gluten introduction (before 4 months of age) as well as cow milk introduction before 12 months of life. These detrimental feeding habits create a gut microbiota dysbiotic state that can contribute to the onset of T1D in infancy. Finally, we discussed the possibility to introduce probiotics, prebiotics and post-biotics in the prevention of T1D.

Indexed as

early nutritiongut microbiotapost-bioticsprebioticsprobioticsT1D

Identifiers

PMID33425976
PMCPMC7785819
OpenAlexW3115005988

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.