ArticleCerebral cortex (New York, N.Y. : 1991)2021
Heritability of Functional Connectivity in Resting State: Assessment of the Dynamic Mean, Dynamic Variance, and Static Connectivity across Networks.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Frontoparietal control-default mode connectivity predicts TMS effects on cognitive control.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Article
- Large-scale cortical functional networks are organized in structured cycles.Nature neuroscience · 2025Article
- Genetic contributions to brain criticality and its relationship with human cognitive functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic and environmental contributions to ReHo and fALFF in early adolescence vary across brain regions.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Modulatory Neurotransmitter Genotypes Shape Dynamic Functional Connectome Reconfigurations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns.Frontiers in computational neuroscience · 2025Article
- Comparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Heritability of functional gradients in the human subcortico-cortical connectivity.Communications biology · 2024Article
- Dissociation of Reliability, Heritability, and Predictivity in Coarse- and Fine-Scale Functional Connectomes during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Rapid dynamics of electrophysiological connectome states are heritable.bioRxiv : the preprint server for biology · 2024Article
- Rapid dynamics of electrophysiological connectome states are heritable.Network neuroscience (Cambridge, Mass.) · 2024Article
- Neurogenetics of Brain Connectivity: Current Approaches to the Study (Review).Sovremennye tekhnologii v meditsine · 2024Review
- Graph-matching distance between individuals' functional connectomes varies with relatedness, age, and cognitive score.Human brain mapping · 2023Article
- Genetic and environmental factors influencing neonatal resting-state functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Abnormal dynamic functional connectivity of thalamic subregions in patients with first-episode, drug-naïve major depressive disorder.Frontiers in psychiatry · 2023Article
- Frequency-specific coactivation patterns in resting-state and their alterations in schizophrenia: An fMRI study.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Recent efforts to evaluate the heritability of the brain's functional connectome have predominantly focused on static connectivity. However, evaluating connectivity changes across time can provide valuable insight about the inherent dynamic nature of brain function. Here, the heritability of Human Connectome Project resting-state fMRI data was examined to determine whether there is a genetic basis for dynamic fluctuations in functional connectivity. The dynamic connectivity variance, in addition to the dynamic mean and standard static connectivity, was evaluated. Heritability was estimated using Accelerated Permutation Inference for the ACE (APACE), which models the additive genetic (h2), common environmental (c2), and unique environmental (e2) variance. Heritability was moderate (mean h2: dynamic mean = 0.35, dynamic variance = 0.45, and static = 0.37) and tended to be greater for dynamic variance compared to either dynamic mean or static connectivity. Further, heritability of dynamic variance was reliable across both sessions for several network connections, particularly between higher-order cognitive and visual networks. For both dynamic mean and static connectivity, similar patterns of heritability were found across networks. The findings support the notion that dynamic connectivity is genetically influenced. The flexibility of network connections, not just their strength, is a heritable endophenotype that may predispose trait behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.