Evidence map›Paper›PMID 33433732›Full record

ReviewCurrent genetics2021

Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis.

Tai-Ting Woo, Chi-Ning Chuang, Ting-Fang Wang

Erratum issuedOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tai-Ting WooInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Chi-Ning ChuangInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Ting-Fang WangInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan. tfwang@gate.sinica.edu.tw.ORCID http://orcid.org/0000-0001-6306-9505
Institute of Molecular Biology, Academia Sinica · TW

Funding

Academia Sinica AS-105-TP-B07 and AS108-TP-B07Ministry of Science and Technology, Taiwan MOST106-2311-B-001-016-MY3 and MOST109-2811-B-001-008-MY3
6 · The paper itself

Abstract

The RecA-family recombinase Rad51 is the central player in homologous recombination (HR), the faithful pathway for repairing DNA double-strand breaks (DSBs) during both mitosis and meiosis. The behavior of Rad51 protein in vivo is fine-tuned via posttranslational modifications conducted by multiple protein kinases in response to cell cycle cues and DNA lesions. Unrepaired DSBs and ssDNA also activate Mec1

Indexed as

DNA DamageHomeostasisHomologous RecombinationHumansIntracellular Signaling Peptides and ProteinsMeiosisMitosisProtein Serine-Threonine KinasesRad51 RecombinaseSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsIntracellular Signaling Peptides and ProteinsMEC1 protein, S cerevisiaeProtein Serine-Threonine KinasesRAD51 protein, humanRAD51 protein, S cerevisiaeRad51 RecombinaseSaccharomyces cerevisiae ProteinsTEL1 protein, S cerevisiaeDNA damage responseIntrinsic structural disorderMec1ATR and Tel1ATMProtein homeostasisRad51 phosphorylationS/T-Q cluster domain

Identifiers

PMID33433732
PMCPMC8139929
OpenAlexW4210340585

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.