Evidence map›Paper›PMID 33435397›Full record

ArticleInternational journal of molecular sciences2021

Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes.

Lucia A Seale, Ashley N Ogawa-Wong, Ligia M Watanabe, Vedbar S Khadka, Mark Menor, Daniel J Torres, Bradley A Carlson, Dolph L Hatfield, Marla J Berry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Global loss of selenocysteine lyase in mice drives lipid accumulation in brown adipocytes.American journal of physiology. Endocrinology and metabolism · 2026
    Article
  2. Review
  3. Article
  4. Selenium and selenoproteins in thermogenic adipocytes.Archives of biochemistry and biophysics · 2022
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lucia A SealeDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.ORCID 0000-0002-0686-7516
Ashley N Ogawa-WongDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Ligia M WatanabeDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Vedbar S KhadkaDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA.ORCID 0000-0002-8652-2904
Mark MenorDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Daniel J TorresDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.ORCID 0000-0002-4451-712X
Bradley A CarlsonMolecular Biology of Selenium Section, Mouse Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1277-7357
Dolph L HatfieldMolecular Biology of Selenium Section, Mouse Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Marla J BerryPacific Biomedical Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
University of Hawaiʻi at Mānoa · USNational Institutes of Health · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI JoAnn Umilani Tsark · 2017 to 2026
$59.5M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2M
Small Grants ProgramP30GM114737 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI NERURKAR, VIVEK RAMCHANDRA · 2015 to 2022
$8.1M
MECHANISM OF SELENOPROTEIN SYNTHESIS IN EUKARYOTESR01DK047320 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 1994 to 2020
$5.8M
Investigating sex-specific metabolic effects of disrupted selenocysteine lyase and selenocysteine tRNA in Agrp hypothalamic neuronsF32DK124963 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI TORRES, DANIEL J. · 2020 to 2022
$206k
NIDDK NIH HHS F32 DK124963NIDDK NIH HHS R01 DK047320NIGMS NIH HHS P30 GM114737NIH HHS P20GM103466NIH HHS P30CA071789NIH HHS P30GM114737NIH HHS R01DK047320NIH HHS R01DK04732022S2NIH HHS R01DK047320-22SS1NIH HHS U54MD007601NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Selenoproteins are a class of proteins with the selenium-containing amino acid selenocysteine (Sec) in their primary structure. Sec is incorporated into selenoproteins via recoding of the stop codon UGA, with specific

Indexed as

ThermogenesisAdipocytes, BrownAdipose Tissue, BrownAnimalsBiosynthetic PathwaysCells, CulturedCold-Shock ResponseEnergy MetabolismFemaleGene DeletionMaleMiceMice, Inbred C57BLRNA, Transfer, Amino Acid-SpecificSelenoproteinsUncoupling Protein 1RNA, Transfer, Amino Acid-SpecificSelenoproteinstRNA, selenocysteine-Ucp1 protein, mouseUncoupling Protein 1brown adipose tissueSec-tRNA[Ser]Secselenoproteins

Identifiers

PMID33435397
PMCPMC7827413
OpenAlexW3120508496

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.