Evidence map›Paper›PMID 33436730›Full record

ArticleScientific reports2021

Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model.

Susanne M Brunner, Florian Reichmann, Julia Leitner, Soraya Wölfl, Stefan Bereswill, Aitak Farzi, Anna-Maria Schneider, Eckhard Klieser, Daniel Neureiter, Michael Emberger and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?Comprehensive reviews in food science and food safety · 2026
    Pooled it
  2. Biochemical and Physiological Effects of Galanin in Health and Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Detection of galanin receptors in the spinal cord in experimental autoimmune encephalomyelitis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. The Role of Neuropeptides in Pathogenesis of Dry Dye.Journal of clinical medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Susanne M BrunnerResearch Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria. su.brunner@salk.at.
Florian ReichmannResearch Unit of Translational Neurogastroenterology, Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria.
Julia LeitnerResearch Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria.
Soraya WölflLaboratory for Pathology Weger, Emberger, Strubergasse 20, 5020, Salzburg, Austria.
Stefan BereswillInstitute of Microbiology, Infectious Diseases and Immunology, Charité - University Medicine Berlin, Garystr. 5, 14195, Berlin, Germany.
Aitak FarziResearch Unit of Translational Neurogastroenterology, Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria.
Anna-Maria SchneiderDepartment of Pediatrics, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria.
Eckhard KlieserInstitute of Pathology, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria.
Daniel NeureiterInstitute of Pathology, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria.
Michael EmbergerLaboratory for Pathology Weger, Emberger, Strubergasse 20, 5020, Salzburg, Austria.
Markus M HeimesaatInstitute of Microbiology, Infectious Diseases and Immunology, Charité - University Medicine Berlin, Garystr. 5, 14195, Berlin, Germany.
Daniel WeghuberDepartment of Pediatrics, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria.
Roland LangDepartment of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria.
Peter HolzerResearch Unit of Translational Neurogastroenterology, Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria.
Barbara KoflerResearch Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Muellner Hauptstr. 48, 5020, Salzburg, Austria.
Paracelsus Medical University · ATMedical University of Graz · ATCharité - Universitätsmedizin Berlin · DE

Funding

Austrian Science Fund FWF P 25912Austrian Science Fund FWF P 32403
6 · The paper itself

Abstract

The regulatory (neuro)peptide galanin and its three receptors (GAL

Indexed as

Gastrointestinal MicrobiomeGene ExpressionAnimalsColitis, UlcerativeCrohn DiseaseHumansInflammationMiceMice, Inbred C57BLMice, KnockoutMolecular Targeted TherapyRatsReceptor, Galanin, Type 3GALR3 protein, mouseReceptor, Galanin, Type 3

Identifiers

PMID33436730
PMCPMC7803768
OpenAlexW3120175500

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.