ArticleScientific reports2021
Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Addressing Pain Using a Mediterranean Ketogenic Nutrition Program in Older Adults with Mild Cognitive Impairment.Journal of pain research · 2024Trial
- Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD-a randomized controlled trial.Cell reports. Medicine · 2023Trial
- Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure.Immunological reviews · 2026Review
- Fueling failure or fostering fusion? A critical review of the potential effect of ketogenic, intermittent fasting, and low-carbohydrate diets on dental implant osseointegration.The Saudi dental journal · 2026Review
- No evidence of immediate or persistent analgesic effect from a single dose of psilocybin in three mouse models of pain.Nature communications · 2026Article
- Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models.bioRxiv : the preprint server for biology · 2025Article
- Modulation of pain by ketones: a mini-review.American journal of physiology. Cell physiology · 2025Review
- Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice.ACR open rheumatology · 2025Article
- Ketogenic diet, adenosine, and dopamine in addiction and psychiatry.Frontiers in nutrition · 2025Review
- Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans.Nature medicine · 2024Article
- A Potential Role for the Ketogenic Diet in Alzheimer's Disease Treatment: Exploring Pre-Clinical and Clinical Evidence.Metabolites · 2023Review
- The Ketogenic Effect of SGLT-2 Inhibitors-Beneficial or Harmful?Journal of cardiovascular development and disease · 2023Review
- Ketolysis is required for the proper development and function of the somatosensory nervous system.Experimental neurology · 2023Article
- Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy.Antioxidants & redox signaling · 2023Review
- Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System.bioRxiv : the preprint server for biology · 2023Article
- Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders.Advances in experimental medicine and biology · 2023Review
- Up-Regulation of ProBDNF/p75Journal of inflammation research · 2023Article
- Low-Carbohydrate High-Fat Diet: A SWOC Analysis.Metabolites · 2022Review
- Review
- Pharmacological and non-pharmacological therapeutic interventions for the treatment of spinal cord injury-induced pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Ketogenic diets are very low carbohydrate, high fat, moderate protein diets used to treat medication-resistant epilepsy. Growing evidence suggests that one of the ketogenic diet's main mechanisms of action is reducing inflammation. Here, we examined the diet's effects on experimental inflammatory pain in rodent models. Young adult rats and mice were placed on the ketogenic diet or maintained on control diet. After 3-4 weeks on their respective diets, complete Freund's adjuvant (CFA) was injected in one hindpaw to induce inflammation; the contralateral paw was used as the control. Tactile sensitivity (von Frey) and indicators of spontaneous pain were quantified before and after CFA injection. Ketogenic diet treatment significantly reduced tactile allodynia in both rats and mice, though with a species-specific time course. There was a strong trend to reduced spontaneous pain in rats but not mice. These data suggest that ketogenic diets or other ketogenic treatments might be useful treatments for conditions involving inflammatory pain.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.