SynthesisPublic health nutrition2021
Effects of prenatal artificial sweeteners consumption on birth outcomes: a systematic review and meta-analysis.
Synthesis in Public health nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between low-calorie sweetener consumption during pregnancy and child health: A systematic review and meta-analysis.Maternal & child nutrition · 2025Pooled it
- Consumption of Non-Nutritive Sweetener during Pregnancy and Weight Gain in Offspring: Evidence from Human Studies.Nutrients · 2022Pooled it
- Low- and no-calorie sweeteners and beverages and their associated health outcomes: an umbrella review of systematic reviews and meta-analyses.Nutrition research and practice · 2026Review
- Perceptions of African Migrant Women Regarding Food Consumption During Pregnancy and the Postpartum Period in Australia: A Qualitative Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Article
- Effect of High Intensity Sweeteners on the Reproductive System: From the Onset of Puberty to Menstrual Health: A Comprehensive Review of Human and Animal Evidence.International journal of women's health · 2026Review
- Prevalence and Factors Associated with the Use of Artificial Sweeteners in Nonpregnant, Nonlactating Females of Reproductive Age - A Systematic Review.Current developments in nutrition · 2025Article
- Exploring the impact of artificial sweeteners on diabetes management and glycemic control.Frontiers in nutrition · 2025Review
- Prevalence and determinants of adverse pregnancy outcomes among teenage mothers in the Limbe Health District of Cameroon.The Pan African medical journal · 2025Article
- Chronic Use of Artificial Sweeteners: Pros and Cons.Nutrients · 2024Review
- Patterns and Predictors of Low-Calorie Sweetener Consumption during Pregnancy: Findings from a National Survey.Nutrients · 2023Article
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- Maternal consumption and perinatal exposure to non-nutritive sweeteners: should we be concerned?Frontiers in pediatrics · 2023Review
- Food additives in childhood: a review on consumption and health consequences.Revista de saude publica · 2022Review
- Non-nutritive sweeteners and their impacts on the gut microbiome and host physiology.Frontiers in nutrition · 2022Review
- Interactions of Non-Nutritive Artificial Sweeteners with the Microbiome in Metabolic Syndrome.Immunometabolism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the influence of prenatal artificial sweetener (AS) consumption on birth outcomes.
designSystematic review and meta-analysis.
settingOnline databases (Medline, CINAHL, Embase, Cochrane Library, Scopus, Web of Science, FSTA - the food resource database, and ClinicalTrials.gov) were searched up to 9 April 2020. Studies of all designs (except case studies and reviews) were eligible, which contained information on the relevant population (pregnant women), intervention/exposure (any AS consumption), comparator (no AS consumption) and birth outcomes (preterm delivery, gestational age, birth weight).
resultsFrom 677 citations, ten cohort studies and one randomised controlled trial (n 138 007 women) were included. 'Low' to 'very low' certainty evidence revealed that daily consumption of AS was associated with an increased risk of preterm delivery (three studies, n 129 009; risk ratio = 1·18, 95 % CI 1·09, 1·28, I2 = 9 %), a 24 g increase in birth weight (three studies, n 64 417; mean difference (MD): 23·74 g, 95 % CI 0·89, 45·58, I2 = 0 %) and a 0·11 week decrease in gestational age (three studies, n 64 417; MD: -0·11 weeks, 95 % CI -0·19, -0·03, I2 = 0 %).
conclusions'Low' to 'very low' certainty evidence suggests daily AS consumption during pregnancy is associated with an increased risk of preterm delivery, increased birth weight and decreased gestational age. Additional 'high'-quality research is urgently needed to further assess these relationships.PROSPERO registration number: CRD42019136728.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.