ArticleScientific reports2021
Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 50 citations in OpenAlex.
- Insulin resistance surrogate indices and incident cardiovascular disease across cardiovascular-kidney-metabolic stages 0-3: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.Cardiovascular diabetology · 2026Article
- Article
- Association of various insulin resistance surrogate markers with mortality risk in critically ill patients with ischemic stroke: a retrospective cohort study.Cardiovascular diabetology · 2026Article
- Outcomes of endovascular thrombectomy in acute ischemic stroke patients with insulin resistance.Journal of neurointerventional surgery · 2026Article
- Cumulative exposure to the estimated glucose disposal rate and incident stroke in individuals with cardiovascular-kidney-metabolic syndrome stages 0-4: 6-year longitudinal evidence from CHARLS.Cardiovascular diabetology · 2026Article
- Association of various insulin resistance surrogate indices with aging acceleration and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: insights from CHARLS 2011-2020 data.Cardiovascular diabetology · 2026Article
- Cumulative inflammatory, coagulation, and metabolic abnormalities predict poor 90-day functional outcome after endovascular thrombectomy for large-vessel occlusion acute ischemic stroke.Frontiers in neurology · 2026Article
- Comprehensive evaluation of the prevalent insulin resistance indices for pan-cancer incidence and mortality prediction.Tropical medicine and health · 2025Article
- Article
- Changes in the estimated glucose disposal rate and incident cardiovascular disease in patients with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study in China.BMC cardiovascular disorders · 2025Article
- Joint association of triglyceride-glucose index and obesity indicators with stroke risk: a nationwide prospective cohort study.Scientific reports · 2025Observational
- Can the triglyceride-glucose index predict stroke outcomes? A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Triglyceride-glucose index is a significant predictor of hospital mortality in non-diabetic critically ill patients with ischemic stroke: a retrospective cohort study of the MIMIC-IV database.Acta diabetologica · 2025Article
- Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2025Article
- Article
- Association between cumulative changes of the triglyceride glucose index and incidence of stroke in a population with cardiovascular-kidney-metabolic syndrome stage 0-3: a nationwide prospective cohort study.Cardiovascular diabetology · 2025Article
- Assessment of six insulin resistance surrogate indexes for predicting stroke incidence in Chinese middle-aged and elderly populations with abnormal glucose metabolism: a nationwide prospective cohort study.Cardiovascular diabetology · 2025Article
- Relationship between triglyceride glucose-body mass index baselines and variation with future cardiovascular diseases risk in the middle-aged and elderly individuals.Frontiers in endocrinology · 2025Article
- The mediation of systemic inflammation on insulin resistance and poor prognosis in non-diabetic ischemic stroke patients treated with intravenous thrombolysis.Frontiers in neurology · 2025Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease. However, the relationship between insulin resistance and the prognosis of acute ischemic stroke in non-diabetic patients is unclear. We hypothesized that insulin resistance might affect short-term functional recovery after acute ischemic stroke in non-diabetic patients. Between May 2014 and December 2016, 1377 consecutive patients with acute ischemic stroke were enrolled from a prospectively maintained stroke registry. After excluding patients with transient ischemic attacks (TIA), pre-stroke disabilities, diabetes mellitus, and patients with incomplete evaluations, 517 patients were included in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) score was used to evaluate the degree of insulin resistance. The patients with the highest quartile of log HOMA-IR index scores were younger and had higher fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein, and HbA1c levels. Multivariable logistic regression analysis revealed that log HOMA-IR scores were independently associated with poor prognosis after adjusting for age and sex and p < 0.1 in univariable analysis. Insulin resistance was associated with the poor functional outcome of non-diabetic stroke patients. This evidence supports treating insulin resistance in acute ischemic stroke patients with blood glucose levels within the normal range.
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