SynthesisPloS one2021
Psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features-A systematic review of randomized clinical trials with meta-analysis and Trial Sequential Analysis.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Efficacy of psychological interventions for adolescents with borderline personality disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- The Impact of Psychological Interventions on Functioning in the Context of Borderline Personality Disorder Features for Adolescents and Young Adults: A Systematic Review and Meta-Analysis.Early intervention in psychiatry · 2026Pooled it
- Navigating agitation in neurodevelopmental disorders: A comparative study of pharmacotherapies via network meta-analysis in children and adults with autism spectrum disorder or intellectual disabilities.Journal of psychopharmacology (Oxford, England) · 2025Pooled it
- Effectiveness of outpatient and community treatments for people with a diagnosis of 'personality disorder': systematic review and meta-analysis.BMC psychiatry · 2023Pooled it
- Comparative Efficacy and Acceptability of Psychotherapies for Self-harm and Suicidal Behavior Among Children and Adolescents: A Systematic Review and Network Meta-analysis.JAMA network open · 2021Pooled it
- Adult life outcomes for adolescents 12.4 years after dialectical behavior therapy - a randomized clinical trial.European child & adolescent psychiatry · 2026Trial
- Psychological, social and pharmacological prevention and interventions for young people with emerging, subthreshold or diagnosed personality disorders: A systematic review.European child & adolescent psychiatry · 2026Review
- We are failing the rights of young people with borderline personality disorder.European child & adolescent psychiatry · 2026Article
- Economic evaluation of three forms of early intervention for young people with borderline personality disorder: a within-trial cost-utility analysis from the MOBY clinical trial.European child & adolescent psychiatry · 2026Article
- Recent Innovations and Developmental Considerations in Mentalization-Based Therapy for Adolescents: A Case Illustration.Journal of clinical psychology · 2026Article
- Borderline personality disorder in East Asian adolescents: a comprehensive review of research on assessment, etiology, and treatment.Frontiers in psychiatry · 2026Review
- Beyond Self-Reports: Integrating Cortisol Measurement in Psychotherapy Process Research among Adolescents with Borderline Personality Pathology.Psychotherapy and psychosomatics · 2026Article
- Research Review: What we have learned about early detection and intervention of borderline personality disorder.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- AIR therapy: a pilot study of a clinician-assisted e-therapy for adolescents with borderline personality disorder.Borderline personality disorder and emotion dysregulation · 2025Article
- Trajectory of Non-suicidal Self-Injury among adolescents with borderline personality disorder over a 5-year period.Borderline personality disorder and emotion dysregulation · 2024Article
- The evaluation of a stepped care approach for early intervention of borderline personality disorder.Borderline personality disorder and emotion dysregulation · 2024Article
- Article
- Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Therapeutic and Preventive Interventions in Adolescents with Borderline Personality Disorder: Recent Findings, Current Challenges, and Future Directions.Journal of clinical medicine · 2023Review
- Emotion Regulation Difficulties, Family Functioning, and Well-Being Involved in Non-Suicidal Self-Injury and Suicidal Risk in Adolescents and Young People with Borderline Personality Traits.Children (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo review the effectiveness of psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features.
methodsWe included randomized clinical trials on psychological therapies for adolescents with BPD and BPD features. Data were extracted and assessed for quality according to Cochrane guidelines, and summarized as mean difference (MD) with 95% confidence intervals (CI) for continuous data and as Odds ratios (OR) with 95% CI for dichotomous data. Risk of bias was assessed using Cochrane's risk of bias tool for each domain. When possible, we pooled trials into meta-analyses, and used Trial Sequential Analysis (TSA) to control for random errors. Quality of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE).
results10 trials on adolescents with BPD or BPD features were included. All trials were considered at high risk of bias, and the quality of the evidence was rated as "very low". We did TSA on the primary outcome and found that the required information size was reached. The risk of random error was thus discarded.
conclusionOnly 10 trials have been conducted on adolescents with BPD or BPD features. Of these only few showed superior outcomes of the experimental intervention compared to the control intervention. No adverse effects of the interventions were mentioned. Attrition rates varied from 15-75% in experimental interventions. The overall quality was very low due to high risk of bias, imprecision and inconsistency, which limits the confidence in effect estimates. Due to the high risk of bias, high attrition rates and underpowered studies in this area, it is difficult to derive any conclusions on the efficacy of psychological therapies for BPD in adolescence. There is a need for more high quality trials with larger samples to identify effective psychological therapies for this specific age group with BPD or BPD features.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.