ArticleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2022
The Neurobiology of Pathological Fatigue: New Models, New Questions.
Article in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of non-pharmacological interventions for fatigue in adults with long-term conditions: a synopsis of the EIFFEL mixed-methods evidence synthesis.Health technology assessment (Winchester, England) · 2026Pooled it
- Acute Clinical Effects of Dual-Task Resistance Exercise on Muscle Endurance and Pressure Sensitivity in Patients With Carpal Tunnel Syndrome After Surgery.Musculoskeletal care · 2026Trial
- Decoding IBS: a machine learning approach to psychological distress and gut-brain interaction.BMC gastroenterology · 2024Trial
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2026Article
- Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Physical and cognitive contributions to fatigue perception: The interplay between local muscle fatigue and sensory prediction error.iScience · 2026Article
- Autologous adipose-derived mesenchymal stromal cells for chronic traumatic brain injury.Brain : a journal of neurology · 2026Article
- Network Localization of Fatigue in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Increased neural responsiveness to distractors irrespective of perceptual load explains attention deficit in post-stroke fatigue.Journal of neuropsychology · 2026Article
- Fatigue relief: the contribution of non-invasive neuromodulation (FAREviaNM).Frontiers in neuroscience · 2026Article
- Strategy and Motivation, Rather Than Fatigue, Drive Age-Related Differences in Sustained Attention Performance: Evidence for Decoupled Beta-Band Oscillations.The European journal of neuroscience · 2026Article
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Fatigue relief is possible.Frontiers in integrative neuroscience · 2026Review
- Effectiveness of non-pharmacological interventions for fatigue in long term conditions: systematic review and network meta-analysis.BMJ medicine · 2026Article
- Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases.Nature reviews. Neurology · 2025Review
- Fatigue of Cancer is Distinctly Different than the Fatigue of Chronic Kidney Disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Molecular-Informed Network Analysis Unveils Fatigue-Related Functional Connectivity in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Observational
- Mental fatigue and cognitive functioning in patients presenting with non-enhancing gliomas.Acta neurochirurgica · 2025Article
- Sensor-Based Assessment of Mental Fatigue Effects on Postural Stability and Multi-Sensory Integration.Sensors (Basel, Switzerland) · 2025Article
- Post-stroke fatigue - a multidimensional problem or a cluster of disorders? A case for phenotyping post-stroke fatigue.The Journal of physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The last decade has seen the emergence of new theoretical frameworks to explain pathological fatigue, a much neglected, yet highly significant symptom across a wide range of diseases. While the new models of fatigue provide new hypotheses to test, they also raise a number of questions. The primary purpose of this essay is to examine the predictions of three recently proposed models of fatigue, the overlap and differences between them, and the evidence from diseases that may lend support to the models of fatigue. I also present expansions for the sensory attenuation model of fatigue. Further questions examined here are the following: What are the neural substrates of fatigue? How can sensory attenuation, which underpins agency also explain fatigue? Are fatigue and agency related?
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.