ArticleDiabetes care2021
Not Only Diabetes but Also Prediabetes Leads to Functional Decline and Disability in Older Adults.
Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of the mHealth Supportive Care Program for Family Caregivers of Individuals With Dementia and Diabetes: Pilot Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Long-term impact of Diabetes Prevention Program interventions on walking endurance.Frontiers in public health · 2024Trial
- Psychological resilience in older adults with type 2 diabetes from the Look AHEAD Trial.Journal of the American Geriatrics Society · 2023Trial
- Machine Learning Classification of Current Functional Impairment in Older Adults with Diabetes: Evidence from CHARLS 2015.Journal of clinical medicine · 2026Article
- Association between physical function and type 2 diabetes risk in older adults: a longitudinal analysis from the KoGES-Anseong cohort.European geriatric medicine · 2026Article
- FNDC5/irisin ameliorates diabetes-associated cognitive dysfunction via αVβ5-cAMP signaling to regulate oxidative stress, neuroinflammation and synaptic plasticity.Journal of translational medicine · 2026Article
- Association between time-weighted average glucose concentration or glucose variability and acute kidney injury among coronary artery disease patients with prediabetes.Renal failure · 2025Article
- The association between multimorbidity and intrinsic capacity decline among older adults: the mediating role of frailty.BMC public health · 2025Article
- "Those risks, that preventative work, that is the bedrock of family medicine": A foucauldian discourse analysis of communicating risk for type 2 diabetes among primary care providers.BMC primary care · 2025Article
- A Narrative Review: Relationship Between Glycemic Variability and Emerging Complications of Diabetes Mellitus.Biomolecules · 2025Review
- The "vegetables first" dietary habit correlates with higher-level functional capacity in older adults with diabetes.BMC nutrition · 2024Article
- Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial.JMIR research protocols · 2024Article
- Prediabetes Progression and Regression on Objectively- Measured Physical Function: A Prospective Cohort Study.Diabetes & metabolism journal · 2023Article
- Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged Japanese adults: A 22-year follow up of NIPPON DATA90.Journal of diabetes investigation · 2022Article
- Healthy Behaviors, Leisure Activities, and Social Network Prolong Disability-Free Survival in Older Adults With Diabetes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Gradient association between pulmonary tuberculosis and diabetes mellitus among households with a tuberculosis case: a contact tracing-based study.Scientific reports · 2022Article
- Contributions of Glucose and Hemoglobin A1c Measurements in Diabetes Screening.American journal of clinical pathology · 2022Article
- Kidney Function and Risk of Physical and Cognitive Impairment in Older Persons with Type 2 Diabetes at an Outpatient Clinic with Geriatric Assessment Implementation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association Between Long-Term HbA1c Variability and Functional Limitation in Individuals Aged Over 50 Years: A Retrospective Cohort Study.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiabetes is linked to functional decline, but the impact of prediabetes on physical function is unknown. We aimed to examine and compare the impact of prediabetes and diabetes on physical function and disability progression and to explore whether cardiovascular diseases (CVDs) mediate these associations. RESEARCH DESIGN AND
methodsA cohort of 2,013 participants aged ≥60 from the Swedish National Study on Aging and Care in Kungsholmen, an ongoing population-based longitudinal study, was monitored for up to 12 years. Physical function was measured with chair stand (s) and walking speed (m/s) tests, and disability was measured by summing the numbers of impaired basic and instrumental activities of daily living. Diabetes was identified through medical examinations or clinical records, medication use, or glycated hemoglobin (HbA
resultsAt baseline, 650 (32.3%) had prediabetes and 151 had diabetes (7.5%). In multiadjusted mixed-effect models, prediabetes was associated with an increased chair stand time (β 0.33, 95% CI 0.05-0.61), a decreased walking speed (β -0.006, 95% CI -0.010 to -0.002), and an accelerated disability progression (β 0.05, 95% CI 0.01-0.08), even after controlling for the future development of diabetes. Diabetes led to faster functional decline than prediabetes. In mediation analyses, CVDs mediated 7.1%, 7.8%, and 20.9% of the associations between prediabetes and chair stand, walking speed, and disability progression, respectively.
conclusionsPrediabetes, in addition to diabetes, is associated with faster functional decline and disability, independent of the future development of diabetes. This association may be in part mediated by CVDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.