Evidence map›Paper›PMID 33449147›Full record

ReviewCellular and molecular life sciences : CMLS2021

Mechanisms of meiotic drive in symmetric and asymmetric meiosis.

Alyssa N Kruger, Jacob L Mueller

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. A Vertebrate Toxin-Antidote System That Sabotages Mouse Embryogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  4. Oocyte Kinetochores at the Nexus of Meiotic Drive and Segregation Fidelity.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. A selfish supergene causes meiotic drive through both sexes inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Structural duality enables a single protein to act as a toxin-antidote pair for meiotic drive.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. An egg sabotaging mechanism drives non-Mendelian transmission in mice.bioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Tubulin post-translational modifications in meiosis.Seminars in cell & developmental biology · 2023
    Review
  14. Article
  15. Centromere drive: model systems and experimental progress.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022
    Review
  16. Non-Mendelian transmission of accessory chromosomes in fungi.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022
    Review
  17. Review
  18. Review
  19. Article
  20. Genome Dominance inFrontiers in plant science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alyssa N KrugerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Jacob L MuellerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA. jacobmu@umich.edu.ORCID http://orcid.org/0000-0003-1232-0303
University of Michigan · US

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Roles of X- and Y-palindromic Genes in Mammalian FertilityR01HD094736 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUELLER, JACOB L · 2018 to 2022
$1.8M
National Institute of Child Health and Human Development HD094736National Science Foundation 1256260NICHD NIH HHS R01 HD094736NIGMS NIH HHS T32 GM007544NIGMS NIH HHS T32GM007544
6 · The paper itself

Abstract

Meiotic drive, the non-Mendelian transmission of chromosomes to the next generation, functions in asymmetric or symmetric meiosis across unicellular and multicellular organisms. In asymmetric meiosis, meiotic drivers act to alter a chromosome's spatial position in a single egg. In symmetric meiosis, meiotic drivers cause phenotypic differences between gametes with and without the driver. Here we discuss existing models of meiotic drive, highlighting the underlying mechanisms and regulation governing systems for which the most is known. We focus on outstanding questions surrounding these examples and speculate on how new meiotic drive systems evolve and how to detect them.

Indexed as

Biological EvolutionChromosome SegregationMeiosisAnimalsHumansSpindle ApparatusGerm cellsMeiosisMeiotic driveSelfish genetic elements

Identifiers

PMID33449147
PMCPMC8043981
OpenAlexW3118741846

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.