Evidence map›Paper›PMID 33449435›Full record

ReviewJournal of the peripheral nervous system : JPNS2021

The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases.

M Laura Feltri, Michael R Weaver, Sophie Belin, Yannick Poitelon

Abstract readReview
In one paragraph

Review in Journal of the peripheral nervous system : JPNS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Low-Intensity Ultrasound Stimulates TAZ in Schwann cells.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Myelin Biology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M Laura FeltriHunter James Kelly Research Institute, Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.ORCID 0000-0002-2276-9182
Michael R WeaverHunter James Kelly Research Institute, Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.ORCID 0000-0002-8761-3867
Sophie BelinDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA.
Yannick PoitelonDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA.ORCID 0000-0001-9868-1569

Funding

Laminin Receptors and Signals in Schwann CellsR01NS045630 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SIM, FRASER JAMES · 2003 to 2024
$5.9M
Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve RepairR01NS110627 · NINDS · ALBANY MEDICAL COLLEGE · PI POITELON, YANNICK · 2020 to 2024
$2.1M
NINDS NIH HHS R01 NS045630NINDS NIH HHS R01 NS110627NINDS NIH HHS R01NS110627NINDS NIH HHS R01NS45630
6 · The paper itself

Abstract

Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to their environment by controlling proliferation, migration and differentiation. Many recent studies have focused on characterizing Hippo pathway function and regulation in mammalian cells. Here, we present a brief overview of the major components of the Hippo pathway, as well as their regulation and function. We comprehensively review the studies that have contributed to our understanding of the Hippo pathway in the function of the peripheral nervous system and in peripheral nerve diseases. Finally, we discuss innovative approaches that aim to modulate Hippo pathway components in diseases of the peripheral nervous system.

Indexed as

Peripheral Nervous System DiseasesAdaptor Proteins, Signal TransducingAnimalsGene Expression Regulation, EnzymologicHumansIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesSignal TransductionAdaptor Proteins, Signal TransducingIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesHipponerve injury and regenerationneurofibromatosisperipheral neuropathyschwann cellYAP/TAZ

Identifiers

PMID33449435
PMCPMC8455061

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.