Evidence map›Paper›PMID 33456566›Full record

ArticleTheranostics2021

Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect.

Kui Fan, Li Zeng, Jing Guo, Shuqin Xie, Yuan Yu, Jianwei Chen, Jin Cao, Qinyanqiu Xiang, Siliang Zhang, Yuanli Luo and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

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  12. Current research trends of nanomedicines.Acta pharmaceutica Sinica. B · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Kui FanDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Li ZengDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Jing GuoRadiation Oncology Center, Chongqing University Cancer Hospital, Chongqing University, Chongqing 400030, China.
Shuqin XieDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yuan YuDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Jianwei ChenDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Jin CaoInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Qinyanqiu XiangInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Siliang ZhangDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yuanli LuoInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Qingyue DengDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Qin ZhouDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Yan ZhaoInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Lan HaoInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Zhigang WangInstitute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Ling ZhongDepartment of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Dalian Medical University · CNChongqing Medical University · CNSecond Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoids are widely used in the treatment of nephritis, however, its dose-dependent side effects, such as the increased risk of infection and metabolic disturbances, hamper its clinical use. This study reports a visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system (named as Dex/PFP@LIPs-BMS-α), which specific delivers dexamethasone (Dex) to podocyte targets and reduces systemic side effects.

Indexed as

AnimalsCells, CulturedCreatinineDexamethasoneDrug Delivery SystemsFluorocarbonsGlucocorticoidsHumansImidazolesKidney DiseasesMalePentanesPodocytesRatsRats, Sprague-DawleyReceptor, Melanocortin, Type 1BMS-470539CreatinineDexamethasoneFluorocarbonsGlucocorticoidsImidazolesPentanesperfluoropentaneReceptor, Melanocortin, Type 1dexamethasoneimmune-associated nephropathynano-delivery systempodocyteside effect

Identifiers

PMID33456566
PMCPMC7806481
OpenAlexW3119590639

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.