ArticleProbiotics and antimicrobial proteins2021
Dietary Supplementation of Potential Probiotics Bacillus subtilis, Bacillus licheniformis, and Saccharomyces cerevisiae and Synbiotic Improves Growth Performance and Immune Responses by Modulation in Intestinal System in Broiler Chicks Challenged with Salmonella Typhimurium.
Article in Probiotics and antimicrobial proteins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Effects of In Ovo Probiotic Injection and Dietary Supplementation on Growth Performance, Antioxidant Status, and Selected Culturable Intestinal Microorganisms in Broilers.Probiotics and antimicrobial proteins · 2026Article
- Effect of RISCO-NUTRIFOUR Probiotic on Growth and Carcass Traits in Broilers During Starter and Grower Phases.Food science & nutrition · 2026Article
- Further Evaluation of 1,25(OH)Animals : an open access journal from MDPI · 2026Article
- Salmonella infection in chickens: pathogen, pathogenesis, and dietary non-drug feed additives as alternatives to antibiotics - a comprehensive review.Folia microbiologica · 2026Review
- Investigation of the Immunomodulatory Effects of Combined Prebiotic, Probiotic, and Postbiotic Mixtures in Chicken Ileal Explant Cultures.Animals : an open access journal from MDPI · 2026Article
- Review
- Host genetic and environmental determinants of chicken gut microbiota: A review.Poultry science · 2026Review
- The combination of dietary active dry yeast andAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Single or Combined Supplementation ofVeterinary sciences · 2025Article
- The probioticInfection and immunity · 2025Article
- In Vitro Investigation of the Effects ofAnimals : an open access journal from MDPI · 2025Article
- Impact of synbiotic on growth performance, histo-architectural modulation of lymphoid organ, hematology, blood biochemistry and humoral immune response in naked neck chicken.Tropical animal health and production · 2024Article
- Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens.Poultry science · 2024Article
- Gut microbiota alteration with growth performance, histopathological lesions, and immune responses inVeterinary and animal science · 2023Article
- Beyond probiotics: a narrative review on an era of revolution.Food science and biotechnology · 2023Review
- Article
- DietaryFrontiers in microbiology · 2023Article
- Synbiotics: a New Route of Self-production and Applications to Human and Animal Health.Probiotics and antimicrobial proteins · 2022Review
- Supplemental Enzyme and Probiotics on the Growth Performance and Nutrient Digestibility of Broilers Fed with a Newly Harvested Corn Diet.Animals : an open access journal from MDPI · 2022Article
- Yeast cell wall upregulated cell-mediated immune responses to Newcastle disease virus vaccine.Poultry science · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluates the effects of probiotics and synbiotics on the performance, immune responses, and intestinal morphology, and the expression of immunity-related genes of broiler chicks challenged with Salmonella typhimurium. Three hundred and sixty broiler chicks were divided into six groups, including broiler chicks challenged and non-challenged with S. typhimurium and fed with probiotic, synbiotic, and basal diet without additive. Growth performance (food intake, daily gain, feed conversion ratio, and mortality), immune responses (antibody titer against sheep red blood cells, immunoglobulins G and M), intestinal morphology, lactic acid bacteria population, and the expression of immunity-related genes (interferon-γ, interleukins 6 and 12, and tumor necrosis factor-α) were investigated. The administration of S. typhimurium decreased growth performance (P = 0.0001), immune responses (P = 0.0001), intestinal morphology (P = 0.0001), lactic acid bacteria population (P = 0.0001), and the expression of immunity-related genes (P = 0.0001) of broiler chickens. However, broiler chicks fed with probiotic (P = 0.001) and synbiotic (P = 0.0001) showed better growth performance, immune responses, intestinal morphology, lactic acid bacteria population, and the expression of immunity-related genes in comparison with infected broiler chicks fed with basal diet lack of probiotic and synbiotic. Feeding probiotics (P = 0.001) and synbiotics (P = 0.0001) showed positive effects for challenged and non-challenged broiler chicks. In sum, feeding synbiotic and probiotic alleviated the negative effects of S. typhimurium on growth and immunity of broiler chicks. It can be suggested to apply synbiotic and probiotics as benefit additive against infectious challenges, such as S. typhimurium.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.