ArticleLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2021
Sarcopenia in Children With End-Stage Liver Disease on the Transplant Waiting List.
Article in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Malnutrition, Frailty, and Sarcopenia in Patients With Cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases.Hepatology (Baltimore, Md.) · 2021Guideline
- Inter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.Journal of pediatric gastroenterology and nutrition · 2026Article
- Sarcopenia in pediatric gastroenterology and hepatology: an updated review.Clinical and experimental pediatrics · 2026Article
- Clinical characteristics of attention-deficit/hyperactivity disorder with sarcopenia in children: a case-control study.Pediatric research · 2026Article
- Comparison of body composition between thin and normal-weight sarcopenic children: a single-center, propensity score matching analysis of a large-scale study.BMC pediatrics · 2026Article
- Ultrasound of the rectus femoris as a novel tool to measure sarcopenia in pediatric chronic liver disease.Hepatology communications · 2025Article
- The impact of sarcopenia on the progression of chronic non-bacterial osteomyelitis.Insights into imaging · 2025Article
- Comparing body composition measures in children with end stage liver disease using noninvasive bioimpedance analysis.BMC pediatrics · 2024Observational
- Nutrition in Pediatric Liver Disease.Indian journal of pediatrics · 2024Review
- Impact of sarcopenia on clinical outcomes in pediatric chronic liver disease post-liver transplantation: prevalence and implications.Gastroenterology and hepatology from bed to bench · 2024Article
- Sarcopenia and Fat Mass in Children With Chronic Liver Disease and Its Impact on Liver Transplantation.JPGN reports · 2022Article
- Review
- Perspectives on Sarcopenia as a Predictor for Outcomes in Pediatric Patients with Chronic Liver Disease.Hepatic medicine : evidence and research · 2022Review
- Sarcopenia in children with chronic liver disease: Prevalence and impact on liver transplant outcomes.Frontiers in pediatrics · 2022Article
- Impact of muscle mass on the prognosis of liver transplantation for infants with biliary atresia.Frontiers in pediatrics · 2022Article
- Utility of Preoperative Computed Tomography-Based Body Metrics in Relation to Postoperative Complications in Pediatric Liver Transplantation Recipients.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2021Article
- Review
- Sequential Treatment of Biliary Atresia With Kasai Hepatoportoenterostomy and Liver Transplantation: Benefits, Risks, and Outcome in 393 Children.Frontiers in pediatrics · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia predicts morbidity and mortality in adults with end-stage liver disease (ESLD) and is determined by total psoas muscle area (tPMA) measurement from computed tomography (CT) imaging. Recently developed pediatric age- and sex-specific tPMA growth curves provide the opportunity to ascertain prevalence and impact of sarcopenia in children awaiting liver transplantation (LT). This retrospective single-center study evaluated sarcopenia in children between 1 and 16 years with ESLD and a clinically indicated abdominal CT less than 3 months before first isolated LT. Sarcopenia was defined as tPMA z score less than -2 measured at the intervertebral L4-5 level. Patient demographic, biochemical, and outcome data were recorded. tPMA was compared with other measures of nutritional status using univariate and multivariate logistic analyses. Outcome measures included 1-year morbidity events and mortality after LT. CT images from 25 (64% female) children with median age of 5.50 (interquartile range [IQR], 3.75-11.33) years were reviewed. Ten children (40%) had a tPMA z score less than -2. Sarcopenia was associated with lower z scores for weight (odds ratio [OR], 0.38; P = 0.02), height (OR, 0.32; P = 0.03), and nutritional support before LT (OR, 12.93; P = 0.01). Sarcopenic children had a longer duration of pediatric intensive care unit (PICU) stay (3.50 [IQR, 3.00-6.00] versus 2.00 [IQR, 2.00-3.50] days; P = 0.03). Sarcopenia was prevalent in 40% of children with ESLD awaiting LT, and lower tPMA z score was associated with deficient anthropometrics and need for nutritional support before LT. Post-LT PICU duration was increased in children with sarcopenia, reflecting adverse outcomes associated with muscle loss. Further studies are needed to elucidate the underlying mechanisms of sarcopenia in children with ESLD.
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