Evidence mapPaperPMID 33464299Full record

ReviewThe Journal of cell biology2021

LNCcation: lncRNA localization and function.

Mary Catherine Bridges, Amanda C Daulagala, Antonis Kourtidis

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 886 papers.

0numbers the graph read from it
0cells of the map it votes in
886citing papers in PubMed
108.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

886 citing papers in PubMed, 1,549 citations in OpenAlex.

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826 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mary Catherine BridgesDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC.
Amanda C DaulagalaDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC.
Antonis KourtidisDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC.
Medical University of South Carolina · US

Funding

The Impact of p53 Variants on Liver DiseaseP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2022 to 2025
$10.2M
Proteomics CoreP30DK123704 · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2025 to 2025
$1.1M
NCATS NIH HHS TL1 TR001451NCATS NIH HHS UL1 TR001450NCI NIH HHS R21 CA246233NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK124553NIGMS NIH HHS P20 GM130457
6 · The paper itself

Abstract

Subcellular localization of RNAs has gained attention in recent years as a prevalent phenomenon that influences numerous cellular processes. This is also evident for the large and relatively novel class of long noncoding RNAs (lncRNAs). Because lncRNAs are defined as RNA transcripts >200 nucleotides that do not encode protein, they are themselves the functional units, making their subcellular localization critical to their function. The discovery of tens of thousands of lncRNAs and the cumulative evidence involving them in almost every cellular activity render assessment of their subcellular localization essential to fully understanding their biology. In this review, we summarize current knowledge of lncRNA subcellular localization, factors controlling their localization, emerging themes, including the role of lncRNA isoforms and the involvement of lncRNAs in phase separation bodies, and the implications of lncRNA localization on their function and on cellular behavior. We also discuss gaps in the current knowledge as well as opportunities that these provide for novel avenues of investigation.

Indexed as

RNA TransportAnimalsCell MembraneHumansOrganellesRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID33464299
PMCPMC7816648
OpenAlexW3122576841

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.