ReviewInternational journal of molecular sciences2021
Stress-Induced Hyperglycaemia in Non-Diabetic Patients with Acute Coronary Syndrome: From Molecular Mechanisms to New Therapeutic Perspectives.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Fasting blood glucose-to-glycated hemoglobin ratio and functional outcomes in patients with ischemic stroke following endovascular treatment-a meta-analysis.Frontiers in neurology · 2025Pooled it
- The predictive value of machine learning for mortality risk in patients with acute coronary syndromes: a systematic review and meta-analysis.European journal of medical research · 2023Pooled it
- Stress hyperglycemia ratio and short-term mortality in critically ill septic patients: stratified analysis by diabetes status.BMC infectious diseases · 2026Article
- A new nomogram for predicting the risk of ischemic early neurological deterioration after intravenous thrombolysis in acute ischemic stroke: a multicenter retrospective study.BMC neurology · 2026Article
- Acute-to-chronic glycemic ratio: a promising biomarker for prognosis of diabetic foot ulcers in a multi-center cohort study.Diabetology & metabolic syndrome · 2026Article
- The predictive value of the C-reactive protein-stress hyperglycemia ratio for in-hospital major adverse cardiovascular events in patients with ST-segment elevation myocardial infarction.Frontiers in cardiovascular medicine · 2026Article
- Systemic Inflammation Mediates the Association Between Admission Hyperglycemia and Pulmonary Infection or Prognosis in Acute Ischemic Stroke.Mediators of inflammation · 2026Article
- Association between stress hyperglycemia ratio and 28-day all-cause mortality in critically ill atrial fibrillation patients: a retrospective cohort study based on the MIMIC-IV database.Journal of thoracic disease · 2025Article
- Prognostic worth of admission blood glucose to albumin ratio: evaluation in patients following percutaneous coronary intervention with and without type 2 diabetes mellitus.BMC cardiovascular disorders · 2025Article
- Association between stress hyperglycemia ratio and all-cause mortality in patients with chronic obstructive pulmonary disease.Scientific reports · 2025Article
- Association between preoperative persistent hyperglycemia and postoperative length of hospital in geriatric hip fracture patients.BMC geriatrics · 2025Article
- Stress hyperglycemia ratio linked to all-cause mortality in critically ill patients with ischemic heart disease.BMC cardiovascular disorders · 2025Article
- Association of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stages 0-4: evidence from a large cohort study.Diabetology & metabolic syndrome · 2025Article
- Impact of glycemic control metrics on short- and long-term mortality in transcatheter aortic valve replacement patients: a retrospective cohort study from the MIMIC-IV database.Cardiovascular diabetology · 2025Article
- Association between stress hyperglycemia ratio and all-cause mortality in critically ill patients with sepsis: results from the MIMIC-IV database.European journal of medical research · 2025Observational
- Predicting 28-day all-cause mortality in patients admitted to intensive care units with pre-existing chronic heart failure using the stress hyperglycemia ratio: a machine learning-driven retrospective cohort analysis.Cardiovascular diabetology · 2025Article
- Estimated glucose disposal rate mediates the association between Life's Crucial 9 and congestive heart failure: a population-based study.Frontiers in endocrinology · 2025Article
- Diagnostic Performance of Surrogate Indices of Insulin Resistance Compared with HOMA2-IR in Non-Diabetic Patients with Acute Coronary Syndrome.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Effects of stress hyperglycemia ratio upon long-lasting prognosis in coronary artery disease patients with or lacking chronic renal impairment: findings from a Chinese multi-center observational study.Diabetology & metabolic syndrome · 2024Article
- Correlation between admission hyperglycemia and postoperative pneumonia after hip fracture surgery: A propensity score-matched study.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress-induced hyperglycaemia (SIH) at hospital admission for acute coronary syndrome is associated with poor outcome, especially in patients without known diabetes. Nevertheless, insulin treatment in these subjects was not correlated with the reduction of mortality. This is likely due to the fact that SIH in the context of an acute coronary syndrome, compared to that in known diabetes, represents an epiphenomenon of other pathological conditions, such as adrenergic and renin-angiotensin system over-activity, hyperglucagonaemia, increase of circulating free fatty acids and pancreatic beta-cell dysfunction, which are not completely reversed by insulin therapy and so worsen the prognosis. Thus, SIH may be considered not only as a biomarker of organ damage, but also as an indicator of a more complex therapeutic strategy in these subjects. The aim of this review is to analyse the molecular mechanisms by which SIH may favour a worse prognosis in non-diabetic patients with acute coronary syndrome and identify new therapeutic strategies, in addition to insulin therapy, for a more appropriate treatment and improved outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.