ArticleMetabolites2021
Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E
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Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Modulation of gene expression by traditional Asian antidiabetic nutraceuticals: A review of potential effects.Asia Pacific journal of clinical nutrition · 2025Review
- 1-Deoxynojirimycin with theaflavins ameliorates high-fat diet-induced insulin resistance in mice by modulating the gut microbiota.Frontiers in nutrition · 2025Article
- GαJournal of the Endocrine Society · 2024Article
- Cyclooxygenase products contribute to the exaggerated exercise pressor reflex evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The prostaglandin EAmerican journal of physiology. Endocrinology and metabolism · 2024Article
- The crosstalk between glomerular endothelial cells and podocytes controls their responses to metabolic stimuli in diabetic nephropathy.Scientific reports · 2023Article
- Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort.The Journal of pharmacology and experimental therapeutics · 2023Observational
- Review
- Noncanonical Regulation of cAMP-Dependent Insulin Secretion and Its Implications in Type 2 Diabetes.Comprehensive Physiology · 2023Article
- E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.ESC heart failure · 2023Article
- Plasma Prostaglandin EMetabolites · 2022Article
- Review
- Pharmacological blockade of the EP3 prostaglandin EMolecular metabolism · 2021Article
- Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance.American journal of physiology. Endocrinology and metabolism · 2021Article
- Human Islet Expression Levels of Prostaglandin EACS pharmacology & translational science · 2021Article
- Role of 2‑series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non‑alcoholic fatty liver disease (Review).International journal of molecular medicine · 2021Review
- Special Issue: Islet Inflammation and Metabolic Homeostasis.Metabolites · 2021Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Michael D SchaidDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-3633-5748
Yanlong ZhuDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0003-4909-7336
Nicole E RichardsonDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Chinmai PatibandlaDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-7530-141X
Irene M OngDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53715, USA.
Rachel J FenskeInterdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Joshua C NeumanInterdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Erin GutheryDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Austin ReuterDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Harpreet K SandhuDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Miles H FullerDivision of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL 60612, USA.
Elizabeth D CoxDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Dawn B DavisDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Brian T LaydenDivision of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL 60612, USA.
Allan R BrasierDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-5012-4090
Dudley W LammingDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Ying GeDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Michelle E KimpleDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
University of Wisconsin–Madison · USUniversity of Illinois Chicago · US
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9MBiology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9MThe function and regulation of the novel pregnancy-specific hexokinase HKDC1R01DK104927 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAYDEN, BRIAN THOMAS, REDDY, TIMOTHY E · 2015 to 2024
$7.2MThe regulation of health and longevity by branched-chain amino acidsR01AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Dudley William Lamming · 2018 to 2026
$3.1MGut microbiota, short chain fatty acids, and adiposity across the epidemiologic transitionR01DK111848 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI DUGAS, LARA RUTH · 2017 to 2021
$3.0MMechanisms of diabetes from acute pancreatitis in African Americans and HispanicsU01DK127378 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Brian Thomas Layden, Cemal Yazici · 2020 to 2026
$2.4MThe role of GLP-1 and CCK in the pancreatic islet to promote beta-cell survivalR01DK110324 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIS, DAWN B · 2016 to 2020
$2.0MMolecular Mechanisms of Dysfunctional Prostaglandin Signaling in the Beta-CellR01DK102598 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, MICHELLE E · 2014 to 2018
$1.7MG(alpha)Z signaling in insulin secretion and glucose toleranceK01DK080845 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, MICHELLE E · 2008 to 2010
$301kAmerican Diabetes Association Research Foundation 1-14-BS-115BLRD VA I01 BX003382BLRD VA I01 BX003700BLRD VA I01 BX004031BLRD VA I01 BX004715NCATS NIH HHS UL1 TR002373NCI NIH HHS P30 CA014520NIA NIH HHS R01 AG056771NIA NIH HHS T32 AG000213NIDDK NIH HHS F31 DK109698NIDDK NIH HHS K01 DK080845NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK102598NIDDK NIH HHS R01 DK104927NIDDK NIH HHS R01 DK110324NIDDK NIH HHS R01 DK111848NIDDK NIH HHS U01 DK127378Wisconsin Alumni Research Foundation UW2020 grant
Abstract
The transition from β-cell compensation to β-cell failure is not well understood. Previous works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), encoded by the
Indexed as
beta-cell functiongut microbiomeinflammationinsulin resistanceinsulin secretionobesitypolyunsaturated fatty acidsprostaglandinstype 2 diabetesuntargeted plasma metabolomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.