Evidence map›Paper›PMID 33467550›Full record

ArticleInternational journal of molecular sciences2021

Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.

Elanora Dovat, Chunhua Song, Tommy Hu, Mohammad Atiqur Rahman, Pavan Kumar Dhanyamraju, Morgann Klink, Daniel Bogush, Mario Soliman, Shriya Kane, Mary McGrath and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  9. Reversal ofFrontiers in oncology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Elanora DovatDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-9022-5358
Chunhua SongDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Tommy HuDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Mohammad Atiqur RahmanDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-6009-7316
Pavan Kumar DhanyamrajuDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Morgann KlinkDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Daniel BogushDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Mario SolimanDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Shriya KaneDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Mary McGrathDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Yali DingDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Dhimant DesaiDepartment of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Arati SharmaDepartment of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Chandrika GowdaDepartment of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0003-4582-820X
Pennsylvania State University · US

Funding

Penn State Institutional Career Development CoreKL2TR002015 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VAN SCOY, LAUREN JODI · 2016 to 2025
$7.8M
Hyundai Hope On Wheels NANCATS NIH HHS KL2 TR002015Penn State College of Medicine NARally Foundation NASt. Baldrick's Foundation NA
6 · The paper itself

Abstract

IKAROS, encoded by the

Indexed as

Gene Expression Regulation, LeukemicCasein Kinase IICell Line, TumorChromatin Assembly and DisassemblyClass I Phosphatidylinositol 3-KinasesHEK293 CellsHumansIkaros Transcription FactorNaphthyridinesPhenazinesPhosphatidylinositol 3-KinasesPhosphorylationPrecursor T-Cell Lymphoblastic Leukemia-LymphomaPromoter Regions, GeneticProtein BindingSignal TransductionCasein Kinase IIClass I Phosphatidylinositol 3-KinasesIkaros Transcription FactorIKZF1 protein, humanNaphthyridinesPhenazinesPhosphatidylinositol 3-KinasesPIK3CD protein, humanPIKFYVE protein, humansilmitasertibIKAROSPI3Kprotein kinase CK2T cell acute lymphoblastic leukemiatranscriptional regulation

Identifiers

PMID33467550
PMCPMC7830534
OpenAlexW3120656404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.