Evidence map›Paper›PMID 33467951›Full record

GuidelineIntegrative cancer therapies

Nursing Procedures for the Prevention and Treatment of Mucositis Induced by Cancer Therapies: Clinical Practice Guideline Based on an Interdisciplinary Consensus Process and a Systematic Literature Search.

Diana Steinmann, Burcu Babadağ Savaş, Sabine Felber, Sosamma Joy, Isabelle Mertens, Holger Cramer, Anna Paul, Monika Layer, Nadja Klafke, Regina Stolz and 12 more

Open access · goldAbstract readPractice Guideline
In one paragraph

Guideline in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Implementing integrative nursing for oncology inpatients: a retrospective analysis of project-related routine data from 2021 to 2023.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 2 countries.

Diana SteinmannMedizinische Hochschule Hannover, Hannover, Germany.
Burcu Babadağ SavaşMedizinische Hochschule Hannover, Hannover, Germany.ORCID 0000-0002-5756-5665
Sabine FelberEvang. Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany.
Sosamma JoyEvang. Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany.
Isabelle MertensEvang. Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany.
Holger CramerEvang. Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany.
Anna PaulEvang. Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany.
Monika LayerKantonsspital St. Gallen, Centre for Integrative Medicine, Sankt Gallen, Switzerland.
Nadja KlafkeUniversity Hospital Heidelberg, Heidelberg, Germany.
Regina StolzUniversity Hospital Tuebingen, Baden-Württemberg, Germany.
Ute HeyderCommunity Hospital Karlsruhe, Karlsruhe, Baden-Württemberg, Germany.
Petra NeubergerUniversity Hospital Heidelberg, Heidelberg, Germany.
Marcela WinklerRobert-Bosch-Krankenhaus Stuttgart, Stuttgart, Baden-Württemberg, Germany.
Christel IdlerRobert-Bosch-Krankenhaus Stuttgart, Stuttgart, Baden-Württemberg, Germany.
Rolf HeineAkademie für Pflegeberufe an der Filderklinik, Filderstadt, Germany.
Elke KaschdailewitschAkademie für Pflegeberufe an der Filderklinik, Filderstadt, Germany.
Heike JohnMedizinische Hochschule Hannover, Hannover, Germany.
Beeke SchmelingMedizinische Hochschule Hannover, Hannover, Germany.
Tatjana ZielkeMedizinische Hochschule Hannover, Hannover, Germany.
Markus HorneberParacelsus Medical University, Klinikum Nürnberg, Germany.
Claudia M WittUniversity Hospital Zurich and University of Zurich, Zurich, Switzerland.
Petra VoissEvang. Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-9005-0479
Kliniken Essen-Mitte · DEMedizinische Hochschule Hannover · DEHeidelberg University · DERobert Bosch Hospital · DEKantonsspital St. Gallen · CHNuremberg Hospital · DESTZ eyetrial · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with cancer receiving tumor therapy often suffer from oral mucositis.

objectivesThe aim of this project was to summarize experiences with nursing procedures by experts in integrative oncology and to establish recommendations for nursing interventions that can prevent or cure mucositis.

methodsThe study design was an interdisciplinary consensus process based on a systematic literature search.

resultsThe panel discussed and agreed on 19 nursing procedures, which included mouthwashes, such as teas, supplements, oil applications, and different kinds of ice cubes to suck, as well as flaxseed solution, propolis, and mare milk. Twelve interventions were classified as effective, with effectiveness for OraLife, propolis, sea buckthorn pulp oil, marshmallow root tea also for xerostomia, Helago chamomile oil, mare milk, and Saliva Natura rated as highly effective in clinical experience. In the systematic literature search, a total of 12 out of 329 randomized controlled trials and meta-analyses on chamomile (n = 3),

conclusionsThe current evidence supports the use of some nursing procedures (f.e. propolis for 2 and 3 grade mucositis) for improving oral mucositis during cancer therapies. There is still a need to define general clinical practice guidelines for the supportive treatment of mucositis, as well as for more interdisciplinary research in this area.

Indexed as

Antineoplastic AgentsMucositisNeoplasmsStomatitisAnimalsConsensusHorsesHumansAntineoplastic Agentschemotherapycomplementaryintegrative medicinemucositisnaturopathicradiotherapyside effectsstomatitis

Identifiers

PMID33467951
PMCPMC7960907
OpenAlexW3122193577

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.