Evidence map›Paper›PMID 33468519›Full record

ArticleDiabetes care2021

Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes.

Laili Soleimani, Ramit Ravona-Springer, Hung-Mo Lin, Xiaoyu Liu, Mary Sano, Anthony Heymann, Michal Schnaider Beeri

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. [Influencing factors of cognitive function decline in elderly patients with type 2 diabetes mellitus].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
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  4. Association of Depression Dimensions With Cognitive Functioning in Community-Dwelling Oldest-Old Adults: The LifeAfter90 Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
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  13. Interactive relationships of Type 2 diabetes and bipolar disorder with cognition: evidence of putative premature cognitive ageing in the UK Biobank Cohort.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  18. Speech markers of depression dimensions across cognitive status.Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Laili SoleimaniDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY laili.soleimani@mssm.edu.ORCID 0000-0002-6440-3322
Ramit Ravona-SpringerThe Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel.
Hung-Mo LinDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-1543-4616
Xiaoyu LiuDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY.
Mary SanoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Anthony HeymannSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Michal Schnaider BeeriDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-4254-9742
Icahn School of Medicine at Mount Sinai · USTel Aviv University · ILJames J. Peters VA Medical Center · USSheba Medical Center · IL

Funding

VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SANO, MARY · 1985 to 2019
$37.9M
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular diseaseR01AG061093 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SCHNAIDER BEERI, MICHAL · 2019 to 2024
$4.3M
Peripheral and brain levels of advanced glycation end products AGEs and incident Alzheimers disease and neuropathologyR01AG053446 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHNAIDER BEERI, MICHAL, URIBARRI, JAIME · 2016 to 2021
$3.8M
Inflammation, long-term diabetes characteristics, and cognitive declineR01AG034087 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHNAIDER BEERI, MICHAL · 2009 to 2014
$3.7M
Hyperbaric oxygen therapy for cognition in diabetic elderly at high dementia riskR01AG051545 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SANO, MARY, SCHNAIDER BEERI, MICHAL · 2016 to 2021
$3.7M
Long term instability of glycemic control and hippocampal functionR21AG043878 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHNAIDER BEERI, MICHAL · 2014 to 2015
$375k
NIA NIH HHS P30 AG066514NIA NIH HHS P50 AG005138NIA NIH HHS R01 AG034087NIA NIH HHS R01 AG051545NIA NIH HHS R01 AG053446NIA NIH HHS R01 AG061093NIA NIH HHS R21 AG043878
6 · The paper itself

Abstract

objectiveDepression is highly frequent in older adults with type 2 diabetes and is associated with cognitive impairment, yet little is known about how various depression dimensions differentially affect cognition. We investigated longitudinal associations of specific depression dimensions with cognitive decline. RESEARCH DESIGN AND

methodsParticipants (

resultsIn the fully adjusted model at baseline, all dimensions of depression, except for anxiety, were associated with some aspect of cognition (

conclusionsApathy was associated with a faster cognitive decline in executive function. These findings highlight the heterogeneity of depression as a clinical construct rather than as a single entity and point to apathy as a specific risk factor for cognitive decline among older adults with type 2 diabetes.

Indexed as

Cognitive DysfunctionDiabetes Mellitus, Type 2AgedCognitionDepressionExecutive FunctionHumansNeuropsychological Tests

Identifiers

PMID33468519
PMCPMC7896256
OpenAlexW3122002101

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.