Evidence map›Paper›PMID 33468559›Full record

ArticleMolecular and cellular biology2021

Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.

Xing Lu, Christophe E Redon, Wei Tang, Swetha Parvathaneni, Bayan Bokhari, Subrata Debnath, Xiao Ling Li, Bruna R Muys, Young Song, Lorinc S Pongor and 8 more

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Xing LuDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA.
Christophe E RedonDevelopmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Wei TangMolecular Epidemiology Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA.
Swetha ParvathaneniDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA.
Bayan BokhariDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA.
Subrata DebnathDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA.
Xiao Ling LiRegulatory RNAs and Cancer Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Bruna R MuysRegulatory RNAs and Cancer Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Young SongOncogenomics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Lorinc S PongorDevelopmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Omar SheikhDivision of Cancer and Stem Cells, Nottingham Breast Cancer Research Centre, University of Nottingham Biodiscovery Institute, Nottingham University Hospitals, Nottingham, United Kingdom.
Andrew R GreenDivision of Cancer and Stem Cells, Nottingham Breast Cancer Research Centre, University of Nottingham Biodiscovery Institute, Nottingham University Hospitals, Nottingham, United Kingdom.
Srinivasan MadhusudanDivision of Cancer and Stem Cells, Nottingham Breast Cancer Research Centre, University of Nottingham Biodiscovery Institute, Nottingham University Hospitals, Nottingham, United Kingdom.
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-4299-8177
Stefan AmbsMolecular Epidemiology Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA.
Javed KhanOncogenomics Section, Genetics Branch, CCR, NCI, NIH, Bethesda, Maryland, USA.
Mirit I AladjemDevelopmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA aladjemm@mail.nih.gov sudha.sharma@howard.edu.
Sudha SharmaDepartment of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA aladjemm@mail.nih.gov sudha.sharma@howard.edu.ORCID 0000-0003-2765-2482
Center for Cancer Research · USHoward University · USNational Institutes of Health · USUniversity of Nottingham · GBGenesis Laboratories · US

Funding

Initiation of DNA Replication in Mammalian CellsZIABC010411 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALADJEM, MIRIT · 2009 to 2025
$25.0M
Novel Markers for Disease Outcome in Breast CancerZIABC010887 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2025
$11.5M
BIOINFORMATICS: SYSTEMS BIOLOGY OF PEDIATRIC CANCERSZIABC011002 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KHAN, JAVED · 2009 to 2025
$9.3M
Advancing aging research through development of minority GerontologistsR25AG047843 · NIA · HOWARD UNIVERSITY · PI DUTTAROY, ATANU · 2014 to 2024
$3.3M
Molecular Analysis of RECQ1 Functions in Genome MaintenanceSC1GM093999 · NIGMS · HOWARD UNIVERSITY · PI SHARMA, SUDHA · 2010 to 2019
$3.0M
NIA NIH HHS R25 AG047843NIGMS NIH HHS SC1 GM093999
6 · The paper itself

Abstract

Susceptibility to breast cancer is significantly increased in individuals with germ line mutations in

Indexed as

Breast NeoplasmsCell Line, TumorEstrogen Receptor alphaEstrogensGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHepatocyte Nuclear Factor 3-alphaHumansRecQ HelicasesESR1 protein, humanEstrogen Receptor alphaEstrogensHepatocyte Nuclear Factor 3-alphaRecQ HelicasesRECQL protein, humanDNA helicaseestrogen receptorFOXA1RECQ1transcriptional regulation

Identifiers

PMID33468559
PMCPMC8088126
OpenAlexW3124719089

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.