Evidence map›Paper›PMID 33477721›Full record

ReviewBiomedicines2021

The Biology of Vasopressin.

Samantha Sparapani, Cassandra Millet-Boureima, Joshua Oliver, Kathy Mu, Pegah Hadavi, Tamar Kalostian, Nazifa Ali, Carla Maria Avelar, Marion Bardies, Brenton Barrow and 63 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Endogenous mediators in regulating primary dysmenorrhea.Frontiers in cell and developmental biology · 2026
    Review
  7. SpecificTheranostics · 2026
    Article
  8. Neuropeptides and the Autonomic Nervous System in Prader-Willi Syndrome.International journal of molecular sciences · 2025
    Review
  9. Review
  10. Review
  11. A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases.Journal of the American Society of Nephrology : JASN · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Discovery and evaluation of a novelActa pharmaceutica Sinica. B · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors at 1 institution in 1 country.

Samantha SparapaniBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Cassandra Millet-BoureimaBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0002-1521-0778
Joshua OliverBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Kathy MuBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Pegah HadaviBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Tamar KalostianBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0002-0027-8956
Nazifa AliBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Carla Maria AvelarBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Marion BardiesBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Brenton BarrowBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Minky BenediktBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Giuliana BiancardiBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Raminder BindraBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Lisa BuiBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Zakaria ChihabBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Ashley CossittBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Jeffrey CostaBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Tina DaigneaultBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Jocelyn DaultBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Isa DavidsonBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0001-9282-7475
Jonathan DiasBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0002-7842-0115
Emie DufourBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Sabine El-KhouryBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Nargess FarhangdoostBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Anika ForgetBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Alexa FoxBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Myriam GebraelBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Maria Concetta GentileBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Olivia GeraciBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Ansley GnanapragasamBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Elias GomahBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Elie HaberBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Claudia HamelBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0002-2648-7369
Thivya IyankerBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Christina KalantzisBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Sara KamaliBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Elsa KassardjianBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Hryssi Krissy KontosBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Thi Bich Uyen LeBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Daniella LoScerboBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Yan Fang LowBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Danielle Mac RaeBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Flore MaurerBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Sana MazharBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Alice NguyenBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Kathy Nguyen-DuongBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Chelsea Osborne-LarocheBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Hwi Wun ParkBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Emilie ParolinBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Kahlila Paul-ColeBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Leah Sarah PeerBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0001-6516-4522
Margaux PhilipponBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Charles-Alexandre PlaisirBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Jessica Porras MarroquinBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Simran PrasadBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Rewaparsad RamsarunBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Saad RazzaqBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Samantha RhaindsBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Damien RobinBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Ryan ScartozziBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Davindra SinghBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Sajad Soleimani FardBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Maxim SorokoBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Nastaran Soroori MotlaghBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Kiri SternBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0002-5720-2581
Laila ToroBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
M Wyatt ToureBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0002-8643-092X
Stephanie Tran-HuynhBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Sarah Trépanier-ChicoineBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Claudia WaddinghamBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Aaliyah Jasmine WeekesBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Allison WisniewskiBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.
Chiara GamberiBiology Department, Concordia University, Montreal, QC H4B 1R6, Canada.ORCID 0000-0002-7122-6491
Concordia University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis in several cell types, storage in intracellular vesicles, and release in response to physiological stimuli are highly regulated and mediated by three distinct G protein coupled receptors. Other receptors may bind or cross-bind vasopressin. Vasopressin is regulated spatially and temporally through transcriptional and post-transcriptional mechanisms, sex, tissue, and cell-specific receptor expression. Anomalies of vasopressin signaling have been observed in polycystic kidney disease, chronic heart failure, and neuropsychiatric conditions. Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.

Indexed as

cardiac functionGPCRsrenal functionsex differencessocial behaviorvasopressin

Identifiers

PMID33477721
PMCPMC7832310
OpenAlexW3123571002

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.