ArticleNeuron2021
Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06853977 (Understanding the Role of Monoaminergic Neurotransmitters in Cognitive Functions Using Fast-cyclic Voltammetry in Patients With Neurological and Psychiatric Diseases Eligible for Neurosurgical Treatment), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Understanding the Role of Monoaminergic Neurotransmitters in Cognitive Functions Using Fast-cyclic Voltammetry in Patients With Neurological and Psychiatric Diseases Eligible for Neurosurgical Treatment (COGAMINE)
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Beyond the brake: The subthalamic nucleus predominantly facilitates action in non-human primates.Progress in neurobiology · 2026Article
- Motor cortex directly excites the substantia nigra pars reticulata, the basal ganglia output nucleus.Nature communications · 2026Article
- Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation.Nature communications · 2026Article
- A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context.PLoS biology · 2026Article
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- The graded effect of propofol in electrophysiology-guided navigation during deep brain stimulation surgery.NPJ Parkinson's disease · 2026Article
- Cortico-basal ganglia dynamics of global and selective response inhibition in humans.bioRxiv : the preprint server for biology · 2026Article
- Subthalamic nucleus in patients with Parkinson's disease encodes changes and magnitude of applied force.NPJ Parkinson's disease · 2026Article
- Single-Neuron Recordings Research in Children: Ethical Considerations, Feasibility, Technical Aspects, and Scientific Opportunities.Pediatric neurosurgery · 2026Review
- Beyond the Brake: the Subthalamic Nucleus Predominantly Facilitates Action in Non-human Primates.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson's disease and dystonia.NPJ Parkinson's disease · 2025Article
- Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes.Annals of neurology · 2025Article
- B(RAIN)Scientific data · 2025Article
- Genetic Etiology Influences the Low-Frequency Components of Globus Pallidus Internus Electrophysiology in Dystonia.European journal of neurology · 2025Article
- Computational mechanism underlying switching of motor actions.PLoS computational biology · 2025Article
- Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy.NPJ Parkinson's disease · 2025Article
- Cognitive Control.Annual review of psychology · 2025Review
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5 authors.
Funding
Abstract
The subthalamic nucleus (STN) supports action selection by inhibiting all motor programs except the desired one. Recent evidence suggests that STN can also cancel an already selected action when goals change, a key aspect of cognitive control. However, there is little neurophysiological evidence for dissociation between selecting and cancelling actions in the human STN. We recorded single neurons in the STN of humans performing a stop-signal task. Movement-related neurons suppressed their activity during successful stopping, whereas stop-signal neurons activated at low-latencies near the stop-signal reaction time. In contrast, STN and motor-cortical beta-bursting occurred only later in the stopping process. Task-related neuronal properties varied by recording location from dorsolateral movement to ventromedial stop-signal tuning. Therefore, action selection and cancellation coexist in STN but are anatomically segregated. These results show that human ventromedial STN neurons carry fast stop-related signals suitable for implementing cognitive control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.