Evidence map›Paper›PMID 33484329›Full record

ArticleAnalytical and bioanalytical chemistry2021

Rapid, user-friendly, and inexpensive detection of azidothymidine.

Ying Luo, Tianwei Jia, Jieqiong Fang, Dandan Liu, Varma Saikam, Xiaolin Sheng, Suri S Iyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ying Luo *788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30302, USA.
Tianwei Jia *788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30302, USA.
Jieqiong Fang788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30302, USA.
Dandan Liu788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30302, USA.
Varma Saikam788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30302, USA.
Xiaolin Sheng788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30302, USA.
Suri S Iyer788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30302, USA. siyer@gsu.edu.ORCID http://orcid.org/0000-0002-6196-006X
Georgia State University · US

Funding

Towards point of care HIV detection using repurposed glucose metersR33AI140475 · NIAID · UNIVERSITY OF MASSACHUSETTS LOWELL · PI IYER, SURI SARANATHAN · 2022 to 2023
$1.6M
Towards point of care HIV detection using repurposed glucose metersR61AI140475 · NIAID · GEORGIA STATE UNIVERSITY · PI IYER, SURI SARANATHAN · 2019 to 2021
$1.4M
NIAID NIH HHS R33 AI140475NIAID NIH HHS R61 AI140475
6 · The paper itself

Abstract

Strict adherence to highly active antiretroviral therapy (HAART) is very important to improve the quality of life for HIV-positive patients to reduce new infections and determine treatment success. Azidothymidine (AZT) is an antiretroviral drug commonly used in HAART treatment. In this research, an "add, mix, and measure" assay was developed to detect AZT within minutes. Three different probes designed to release fluorophores when samples containing AZT are added were synthesized and characterized. The limit of detection to AZT in simulated urine samples was determined to be 4 μM in 5 min for one of the probes. This simple and rapid point-of-care test could potentially be used by clinicians and health care workers to monitor the presence of AZT in low resource settings.

Indexed as

AntibodiesAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveAzidesCalibrationEnzyme-Linked Immunosorbent AssayFluorescent DyesHIV InfectionsHumansLimit of DetectionMagnetic Resonance SpectroscopyMicroscopy, FluorescencePoint-of-Care TestingQuality of LifeReproducibility of ResultsUrineAntibodiesAnti-HIV AgentsAzidesFluorescent DyesZidovudineAzidothymidineFluorescenceHIVPoint-of-careTherapeutic drug monitoring

Identifiers

PMID33484329
PMCPMC8276851
OpenAlexW3121967422

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.