ArticleMitochondrion2021
Mitochondria and early-life adversity.
Article in Mitochondrion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Associations of Mitochondrial Function, Stress, and Neurodevelopmental Outcomes in Early Life: A Systematic Review.Developmental neuroscience · 2022Pooled it
- RNA in Plasma Extracellular Vesicles of Adolescent Rhesus Macaques Reveals Immune, Bioenergetic, and Microbial Imprints of Early-Life Adversity: An Exploratory Analysis.Biological psychiatry · 2026Article
- Blood mitochondrial metabolism predicts flight performance without lasting effects of early-life thyroid hormones.iScience · 2026Article
- Sex-specific programming of the gastric and duodenal mitochondrial biogenesis by early-life stress.Genes & genomics · 2025Article
- Early life stress, psychiatric conditions, and mitochondrial DNA copy number (mtDNAcn) in medically healthy young adults.Psychoneuroendocrinology · 2025Article
- Article
- The Role of Mitochondrial Energy Metabolism in the Mechanism of Exercise Improving Depression.Current issues in molecular biology · 2025Review
- Increased Rate of Unique Mitochondrial DNA Deletion Breakpoints in Young Adults With Early-Life Stress.Biological psychiatry global open science · 2025Article
- Telomere length and mitochondrial DNA copy number in association with trauma-focused psychotherapy efficacy.Neuroscience applied · 2025Article
- Early Handling Exerts Anxiolytic Effects and Alters Brain Mitochondrial Dynamics in Adult High Anxiety Mice.Molecular neurobiology · 2024Article
- Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.Developmental psychology · 2024Review
- Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor.Brain, behavior, and immunity · 2024Article
- Childhood adverse life events and skeletal muscle mitochondrial function.Science advances · 2024Article
- Examining the Biological Impacts of Parent-Child Relationship Dynamics on Preschool-Aged Children who have Experienced Adversity.Developmental psychobiology · 2024Observational
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- A method for measuring mitochondrial DNA copy number in pediatric populations.Frontiers in pediatrics · 2024Article
- Sex differences in childhood maltreatment, inflammation, and adulthood depression: A network analysis.Brain, behavior, & immunity - health · 2023Article
- Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania.Molecular psychiatry · 2023Article
- Early life stress induces irritable bowel syndrome from childhood to adulthood in mice.Frontiers in microbiology · 2023Article
- Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland.Frontiers in pharmacology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Early-life adversity (ELA), which includes maltreatment, neglect, or severe trauma in childhood, increases the life-long risk for negative health outcomes. Mitochondria play a key role in the stress response and may be an important mechanism by which stress is transduced into biological risk for disease. By responding to cues from stress-signaling pathways, mitochondria interact dynamically with physiological stress responses coordinated by the central nervous, endocrine, and immune systems. Preclinical evidence suggests that alterations in mitochondrial function and structure are linked to both early stress and systemic biological dysfunction. Early clinical studies support that increased mitochondrial DNA content and altered cellular energy demands may be present in individuals with a history of ELA. Further research should investigate mitochondria as a potential therapeutic target following ELA.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.