Evidence map›Paper›PMID 33491080›Full record

ArticleAmerican journal of hypertension2021

Association of Longitudinal Changes in NT-proBNP With Changes in Left Atrial Volume and Function: MESA.

Vinithra Varadarajan, Bharath Ambale-Venkatesh, Seo Young Hong, Mohammadali Habibi, Hiroshi Ashikaga, Colin O Wu, Lin Y Chen, Susan R Heckbert, David A Bluemke, Joao A C Lima

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Vinithra VaradarajanDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Bharath Ambale-VenkateshDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Seo Young HongOffice of the Director, Center for Scientific Review, National Institutes of Health, Bethesda, Maryland, USA.
Mohammadali HabibiDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Hiroshi AshikagaDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Colin O WuDepartment of Medicine, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA.
Lin Y ChenCardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
David A BluemkeDepartment of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
Joao A C LimaDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-8756-6995
Johns Hopkins University · USNational Heart Lung and Blood Institute · USNational Institutes of Health · USUniversity of Minnesota · USUniversity of Washington · USUniversity of Wisconsin–Madison · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS R01 HL127659
6 · The paper itself

Abstract

backgroundThe mechanism of left atrial (LA) remodeling is poorly understood. The aim of this longitudinal study was to investigate whether changes in NT-proBNP levels relate to alterations of LA structure and function over time in a multiethnic population.

methodsFrom the prospective cohort study, the Multi-Ethnic Study of Atherosclerosis, our analysis included 1,838 participants who underwent cardiac magnetic resonance imaging at the baseline and 10-year examinations, had NT-proBNP levels available at both time points, and did not develop heart failure, myocardial infarction, and/or atrial fibrillation. Multivariable linear regression was used to analyze the association between NT-proBNP level (log-transformed) at the 2 time points and change in LA volumes, LA emptying fractions (total, active, and passive), and LA longitudinal strain. Log NT-proBNP was categorized into Low-Low (N = 681), Low-High (N = 238), High-Low (N = 237), and High-High (N = 682) based on the median value at both time points.

resultsWith the Low-Low group as the reference group, the High-High group experienced a greater increase in LA maximum and minimum indexed volumes: 3.1 ml/m2 (95% confidence interval 1.98, 4.20) and 2.7 ml/m2 (1.89, 3.51), respectively. The High-High group also experienced a greater decrease in LA total, passive, active emptying fraction, and longitudinal strain: -3.3% (-4.46, -2.11), -0.9% (-1.80, -0.02), -4.2% (-5.55, -2.76), and -2.3% (-3.80, -0.72), respectively. The Low-High group had similar associations, but the effect sizes were not as high.

conclusionsAdverse LA remodeling over 10 years of follow-up strongly correlates with prolonged elevated levels of intracardiac stress, as assessed by NT-proBNP levels.

Indexed as

Atrial FunctionHeart AtriaNatriuretic Peptide, BrainPeptide FragmentsAtrial RemodelingHumansLongitudinal StudiesOrgan SizeProspective StudiesNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)blood pressurecardiac magnetic resonance imaginghypertensionleft atriummultimodality tissue trackingNT-proBNP

Identifiers

PMID33491080
PMCPMC8219363
OpenAlexW3123432826

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.