Evidence map›Paper›PMID 33491589›Full record

ArticlePhysiological genomics2021

The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature.

Shannon C Kelly, Christoph D Rau, An Ouyang, Pamela K Thorne, T Dylan Olver, Jenna C Edwards, Timothy L Domeier, Jaume Padilla, Laurel A Grisanti, Bradley S Fleenor and 3 more

Open access · greenAbstract read
In one paragraph

Article in Physiological genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Shannon C KellyDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.
Christoph D RauDepartment of Computational Medicine and Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
An OuyangDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Pamela K ThorneDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.
T Dylan OlverDepartment of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Jenna C EdwardsDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.
Timothy L DomeierDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
Jaume PadillaDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Laurel A GrisantiDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.
Bradley S FleenorHuman Performance Laboratory, School of Kinesiology, Ball State University, Muncie, Indiana.
Yibin WangDavid Geffen School of Medicine, University of California, Los Angeles, California.
R Scott RectorDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Craig A EmterDepartment of Biomedical Sciences, University of Missouri, Columbia, Missouri.ORCID 0000-0003-1251-591X
University of Missouri · USBall State University · USHarry S. Truman Memorial Veterans' Hospital · USHarvard University · USUniversity of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USUniversity of Saskatchewan · CA

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Cardiomyocyte TRPV4 and cardiac dysfunction following ischemia-reperfusion in the aged heart.R01HL136292 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Timothy Lee Domeier · 2017 to 2026
$3.5M
Epigenomic Mechanisms of Heart FailureR01HL129639 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VONDRISKA, THOMAS M. · 2015 to 2018
$2.6M
A Systems Approach to Dissect Genetic Basis of Heart FailureR01HL123295 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, WANG, YIBIN · 2014 to 2017
$2.6M
Coronary Dysfunction, BK Channels, & Exercise in Heart FailureR01HL112998 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI EMTER, CRAIG ALLEN · 2014 to 2018
$1.8M
BCAA Catabolic Defect in HF: Novel Mechanism and Therapeutic TargetR01HL140116 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, ZHAOPING · 2018 to 2021
$1.6M
Novel Regulatory Circuit in Cardiac Hypertrophy Via RNA SplicingR01HL122737 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2014 to 2017
$1.5M
Vascular Insulin Resistance in Obesity: Role of Endoplasmic Reticulum StressK01HL125503 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2015 to 2018
$564k
Cardiomyocyte stretch and intracellular calcium release with advancing ageK01AG041208 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI DOMEIER, TIMOTHY LEE · 2012 to 2016
$545k
Discovery of Novel Epigenetic Regulators of Heart Failure in a Panel of MiceK99HL138301 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAU, CHRISTOPH DANIEL · 2018 to 2019
$239k
Hepatic eNOS in the regulation of NASHI01BX003271 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI RANDY SCOTT RECTOR · 2017 to 2026
–
American Heart Association-American Stroke Association 16POST27760052BLRD VA I01 BX003271NHLBI NIH HHS HL129639NHLBI NIH HHS K01 HL125503NHLBI NIH HHS K99 HL138301NHLBI NIH HHS R01 HL112998NHLBI NIH HHS R01 HL122737NHLBI NIH HHS R01 HL123295NHLBI NIH HHS R01 HL129639NHLBI NIH HHS R01 HL136292NHLBI NIH HHS R01 HL140116NHLBI NIH HHS RO1 HL112998NIA NIH HHS K01 AG041208NIDDK NIH HHS P30 DK097512VA I01BX003271-01
6 · The paper itself

Abstract

Heart failure (HF) patients with deteriorating right ventricular (RV) structure and function have a nearly twofold increased risk of death compared with those without. Despite the well-established clinical risk, few studies have examined the molecular signature associated with this HF condition. The purpose of this study was to integrate morphological, molecular, and functional data with the transcriptome data set in the RV of a preclinical model of cardiometabolic HF. Ossabaw swine were fed either normal diet without surgery (lean control,

Indexed as

TranscriptomeAnimalsCoronary VesselsDiet, WesternFemaleGene Expression ProfilingGene OntologyGene Regulatory NetworksHeart FailureHeart VentriclesHumansMyocardiumRNA-SeqSignal TransductionSwineVentricular Remodelingcardiometabolicheart failureOssabaw swineright coronary arteryright ventricle transcriptome

Identifiers

PMID33491589
PMCPMC7988741
OpenAlexW3123867674

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.