Evidence map›Paper›PMID 33494263›Full record

ArticleInternational journal of molecular sciences2021

Corticotropin-Releasing Hormone Receptor Alters the Tumor Development and Growth in

Yunna Lee, Elise L Ma, Marisa Patel, Gayoung Kim, Cody Howe, Charalabos Pothoulakis, Yong Sung Kim, Eunok Im, Sang Hoon Rhee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yunna LeeCollege of Pharmacy, Pusan National University, Busan 46241, Korea.
Elise L MaInflammatory Bowel Disease Center, and Center for Systems Biomedicine, Vatcher and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.ORCID 0000-0003-4662-2262
Marisa PatelDepartment of Biological Sciences, Oakland University, Rochester, MI 48309, USA.
Gayoung KimDepartment of Biological Sciences, Oakland University, Rochester, MI 48309, USA.
Cody HoweDepartment of Biological Sciences, Oakland University, Rochester, MI 48309, USA.
Charalabos PothoulakisInflammatory Bowel Disease Center, and Center for Systems Biomedicine, Vatcher and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Yong Sung KimDigestive Disease Research Institute and GutnFood Healthcare Inc., School of Medicine, Wonkwang University, Iksan 54538, Korea.ORCID 0000-0001-8836-4818
Eunok ImCollege of Pharmacy, Pusan National University, Busan 46241, Korea.
Sang Hoon RheeDepartment of Biological Sciences, Oakland University, Rochester, MI 48309, USA.ORCID 0000-0003-3816-2657
Oakland University · USPusan National University · KRWonkwang University · KR

Funding

Pusan National University 2-Year Research Grant
6 · The paper itself

Abstract

The neuroendocrine circuit of the corticotropin-releasing hormone (CRH) family peptides, via their cognate receptors CRHR1 and CRHR2, copes with psychological stress. However, peripheral effects of the CRH system in colon cancer remains elusive. Thus, we investigate the role of CRHR1 and CRHR2 in colon cancer. Human colon cancer biopsies were used to measure the mRNA levels of the

Indexed as

AdultAgedAged, 80 and overAnimalsCarcinogensCell Transformation, NeoplasticColonic NeoplasmsCRF Receptor, Type 1Cyclooxygenase 2Disease Models, AnimalFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMiceCarcinogensCRF Receptor, Type 1CRF receptor type 2Cyclooxygenase 2Ptgs2 protein, mouseReceptors, Corticotropin-Releasing HormoneRNA, Messengerazoxymethanecolitiscyclooxygenase 2gastrointestinalneuropeptidestresstumorigenicity

Identifiers

PMID33494263
PMCPMC7864487
OpenAlexW3123750354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.