Evidence map›Paper›PMID 33494340›Full record

ArticleMolecules (Basel, Switzerland)2021

Synergism and Subadditivity of Verbascoside-Lignans and -Iridoids Binary Mixtures Isolated from

Luis David Arango-De la Pava, Alejandro Zamilpa, José Luis Trejo-Espino, Blanca Eda Domínguez-Mendoza, Enrique Jiménez-Ferrer, Leonor Pérez-Martínez, Gabriela Trejo-Tapia

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Neuroprotective Effect of the Combined Extract ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. UnderstandingPathogens (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Luis David Arango-De la PavaCentro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Yautepec, Morelos 62731, Mexico.ORCID 0000-0002-7871-1000
Alejandro ZamilpaCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos 62790, Mexico.ORCID 0000-0002-2233-5958
José Luis Trejo-EspinoCentro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Yautepec, Morelos 62731, Mexico.
Blanca Eda Domínguez-MendozaCentro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos 62209, Mexico.
Enrique Jiménez-FerrerCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos 62790, Mexico.ORCID 0000-0002-0783-8274
Leonor Pérez-MartínezInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, Mexico.
Gabriela Trejo-TapiaCentro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Yautepec, Morelos 62731, Mexico.ORCID 0000-0002-7479-9332
Instituto Politécnico Nacional · MXMexican Social Security Institute · MXUniversidad Autónoma del Estado de Morelos · MXUniversidad Nacional Autónoma de México · MX

Funding

Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional 20200522
6 · The paper itself

Abstract

Pharmacodynamic interactions between plant isolated compounds are important to understand the mode of action of an herbal extract to formulate or create better standardized extracts, phytomedicines, or phytopharmaceuticals. In this work, we propose binary mixtures using a leader compound to found pharmacodynamic interactions in inhibition of the NF-κB/AP-1 pathway using RAW-Blue™ cells. Eight compounds were isolated from

Indexed as

Anti-Inflammatory AgentsGlucosidesIridoidsLignansPhenolsAnimalsCell LineMiceNF-kappa BOrobanchaceaePolyphenolsTranscription Factor AP-1acteosideAnti-Inflammatory AgentsGlucosidesIridoidsLignansNF-kappa BPhenolsPolyphenolsTranscription Factor AP-1AP-1Castilleja tenuifloraNF-κBOrobanchaceaepharmacodynamic interactionsRAW-blue™ cells

Identifiers

PMID33494340
PMCPMC7865359
OpenAlexW3123824730

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.