Evidence map›Paper›PMID 33494474›Full record

ArticleBiomolecules2021

Extra Virgin Olive Oil Phenols Vasodilate Rat MesentericResistance Artery via Phospholipase C (PLC)-CalciumMicrodomains-Potassium Channels (BK

Rossana D'Agostino, Laura Barberio, Mariacarmela Gatto, Teresa Tropea, Maria De Luca, Maurizio Mandalà

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. The Role of the Gut Microbiota in Vascular Physiology and Health.International journal of molecular sciences · 2025
    Review
  2. Influence of Olive Oil Components on Ion Channels.Molecules (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Review
  5. Insulin resistance, CaFrontiers in physiology · 2025
    Review
  6. Extra Virgin Olive Oil and Metabolic Diseases.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Rossana D'AgostinoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Laura BarberioDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Mariacarmela GattoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Teresa TropeaDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Maria De LucaDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-6345-7508
Maurizio MandalàDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0003-3736-0205
University of Calabria · ITManchester Academic Health Science Centre · GBUniversity of Alabama at Birmingham · USUniversity of Vermont · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

Recent evidence suggests that the reason Extra Virgin Olive Oil (EVOO) lowers blood pressure and reduces the risk of developing hypertension is partly due to minor components of EVOO, such as phenols. However, little is still known about the mechanism(s) through which EVOO phenols mediate anti-hypertensive effects. The aim of the present study was to investigate the mechanisms of action of EVOO phenols on mesenteric resistance arteries. A pressure myograph was used to test the effect of EVOO phenols on isolated mesenteric arteries in the presence of specific inhibitors of: 1) BKca channels (Paxillin, 10

Indexed as

AnimalsBlood PressureBoron CompoundsCalcium ChannelsEstrenesInositol 1,4,5-Trisphosphate ReceptorsMaleMembrane MicrodomainsMesenteric ArteriesOlive OilPaxillinPertussis ToxinPhenolPhenolsPotassium ChannelsPyrrolidinones1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione2-aminoethoxydiphenyl borateBoron CompoundsCalcium ChannelsEstrenesInositol 1,4,5-Trisphosphate ReceptorsOlive OilPaxillinPertussis ToxinPhenolPhenolsPotassium ChannelsPyrrolidinonesReceptors, G-Protein-CoupledRyanodineRyanodine Receptor Calcium Release ChannelType C PhospholipasesVerapamilBKCa channelsCa2+ microdomainsGPCR-Gαimesenteric arteryPLC

Identifiers

PMID33494474
PMCPMC7912046
OpenAlexW3123986091

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.