ReviewAntioxidants (Basel, Switzerland)2021
The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors.
Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.Nutrients · 2025Pooled it
- Tuning the Fire: Context-Dependent Mitochondrial ROS Signaling, Mitohormesis, and Redox-Modulating Interventions.Biomolecules · 2026Review
- Cu-MOFs Nanozymes with Ascorbate Oxidase and Peroxidase-like Activity for Sensitive Fluorometric Detection of Total Antioxidant Capacity in Fruits.Nanomaterials (Basel, Switzerland) · 2026Article
- French Propolis Caffeic Acid Derivatives Protect Skeletal Muscle from Oxidative Damages.Biomolecules · 2026Article
- Comparative Analysis of the Pharmacokinetic Characteristics of 2,6-Diisobornyl-4-Methylphenol and Its Metabolites in Rat Bile under Normal Conditions and in Liver Pathology.Bulletin of experimental biology and medicine · 2026Article
- Effects of Citicoline-Based Supplementation on Lipid Peroxidation Markers and Sirtuin-1 Expression in Ischemic Stroke.Current issues in molecular biology · 2026Article
- Bipolar disorder and somatic diseases: Focus on oxidative stress markers.Neuroscience applied · 2026Review
- Significance of Vitamins A and E in Cancer Progression and Prevention.International journal of molecular sciences · 2025Review
- Reductive stress and the role of antioxidants in male infertility: a narrative review.Archives of gynecology and obstetrics · 2025Review
- The Influence of Diabetes Mellitus and Kidney Dysfunction on Oxidative Stress, a Reflection of the Multisystem Interactions in Aortic Stenosis.Antioxidants (Basel, Switzerland) · 2025Article
- Naringin vs.Antioxidants (Basel, Switzerland) · 2025Article
- Feeding Approach to Optimizing Nutrition in Infants with Congenital Heart Disease.Journal of cardiovascular development and disease · 2025Review
- Biomarker changes before and after the 2024 peak burning period in healthy, diabetic, and hypertensive residents of Chiang Mai, Thailand.Frontiers in public health · 2025Article
- Different Oxidative Stress and Inflammation Patterns of Diseased Left Anterior Descending Coronary Artery versus Internal Thoracic Artery.Antioxidants (Basel, Switzerland) · 2024Article
- Food contamination and cardiovascular disease: a narrative review.Internal and emergency medicine · 2024Review
- Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant status in patients with suspected obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Protective effects of fruit extract ofFood science & nutrition · 2023Article
- Nanoparticle-Based Antioxidants in Stress Signaling and Programmed Cell Death in Breast Cancer Treatment.Molecules (Basel, Switzerland) · 2023Review
- Review
- Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin.Antioxidants (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.