Evidence map›Paper›PMID 33499086›Full record

ReviewToxins2021

Antiviral Activity of Ribosome-Inactivating Proteins.

Lucía Citores, Rosario Iglesias, José M Ferreras

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 67 citations in OpenAlex.

  1. Antiviral Potential ofBiomedicines · 2026
    Review
  2. A Novel Cysteine Protease fromPlants (Basel, Switzerland) · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Potential effect ofFrontiers in microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. TMT-Based Proteomic Analysis ofFoods (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lucía CitoresDepartment of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, E-47011 Valladolid, Spain.ORCID 0000-0003-3784-5042
Rosario IglesiasDepartment of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, E-47011 Valladolid, Spain.ORCID 0000-0002-5021-1733
José M FerrerasDepartment of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, E-47011 Valladolid, Spain.ORCID 0000-0003-4816-5878
Universidad de Valladolid · ES

Funding

Consejería de Educación, Junta de Castilla y León VA033G19
6 · The paper itself

Abstract

Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the difficulty in treating viral infections. On the other hand, there is a growing need to control crop diseases without resorting to the use of phytosanitary products which are very harmful to the environment and in this respect, RIPs have been shown as a promising tool that can be used to obtain transgenic plants resistant to viruses. The way in which RIPs exert their antiviral effect continues to be the subject of intense research and several mechanisms of action have been proposed. The purpose of this review is to examine the research studies that deal with this matter, placing special emphasis on the most recent findings.

Indexed as

Pest Control, BiologicalAnimalsAntiviral AgentsHumansPlant DiseasesPlants, Genetically ModifiedProtein Synthesis InhibitorsRibosome Inactivating ProteinsToxins, BiologicalVirus DiseasesVirusesAntiviral AgentsProtein Synthesis InhibitorsRibosome Inactivating ProteinsToxins, Biologicaladenine polynucleotide glycosylaseantiviral therapyhuman virusimmunotoxinribosome-inactivating protein (RIP)rRNA glycosylase (EC 3.2.2.22)virus-resistant transgenic plant (VRTP)

Identifiers

PMID33499086
PMCPMC7912582
OpenAlexW3121908550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.