Evidence mapPaperPMID 33501848Full record

ArticleCirculation2021

Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.

Salim S Virani, Alvaro Alonso, Hugo J Aparicio, Emelia J Benjamin, Marcio S Bittencourt, Clifton W Callaway, April P Carson, Alanna M Chamberlain, Susan Cheng, Francesca N Delling and 30 more

15 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 15 registered trials, which are not on this map. Cited by 3,024 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3,024citing papers in PubMed, 10 pooled it
713.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05082506 naunknown statusnot on this map

Effect of Acupressure on Pain, Anxiety and Vital Signs in Patients With Coronary Angiography: A Randomized Controlled Study

TypeinterventionalSponsorEastern Mediterranean UniversityRan2021 to 2022Enrolled105ConditionsPain, Anxiety, Vital Signs, Coronary AngiographyArmsAcupressure
NCT05338216 nacompletednot on this mapstarted 2022, after this paper: background citation

Word Retrieval in the Wild: An Ecological Momentary Assessment Pilot Study in People With Post-Stroke Aphasia

TypeinterventionalSponsorNortheastern UniversityRan2022 to 2024Enrolled16ConditionsAphasia, AcquiredArmsTraditional EMA, Micro-Interaction EMA
NCT05348044 nacompletednot on this mapstarted 2022, after this paper: background citation

Feasibility Study to Increase Resilience Through an At-home Virtual Exercise Training (Res-ET) Intervention Using Inspiratory Muscle Strength Training (IMST)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2023Enrolled19ConditionsResilience, StrokeArmsRes-ET intervention
NCT05486000 narecruitingnot on this mapstarted 2022, after this paper: background citation

Evaluating the Safety and Efficacy of Atrial Shunt Implantation Systems for the Treatment of Patients With Chronic Left Heart Failure Prospective, Multicenter, Single-group Target Value Clinical Trials

TypeinterventionalSponsorMorningside (Nantong) Medical Co.,LtdRan2022 to 2026Enrolled120ConditionsLeft Heart FailureArmsAtrial shunt implant system
NCT05583513 completednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Progression of Disease and Health-related Quality of Life in Ambulatory Heart Failure Patients: A Local Clinic-based Registry

Typeobservational_patient_registrySponsorChinese University of Hong KongRan2022 to 2023Enrolled500ConditionsHeart FailureArmsMLHFQ (Minnesota Living with Heart Failure Questionnaire), KCCQ (the Kansas City Cardiomyopathy Questionnaire)
NCT05651945 narecruitingnot on this mapstarted 2023, after this paper: background citation

Stroke Recovery Program-Cardiac Rehabilitation of Stroke Survivors

TypeinterventionalSponsorHackensack Meridian HealthRan2023 to 2031Enrolled150ConditionsStroke, Cerebrovascular AccidentArmsCardiac rehabilitation program
NCT05784753 narecruitingnot on this mapstarted 2023, after this paper: background citation

HEART (Heart Failure Exercise and Resistance Training) Camp Connect: Promoting Adherence to Exercise in Adults With Heart Failure With Preserved Ejection Fraction

TypeinterventionalSponsorUniversity of NebraskaRan2023 to 2028Enrolled300ConditionsHFpEF - Heart Failure With Preserved Ejection FractionArmsHEART Camp, HEART Camp Connect
NCT05971407 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of Chronic Remote Ischaemic Preconditioning on Blood Pressure in Older Adults

TypeinterventionalSponsorUniversity of NottinghamRan2022 to 2024Enrolled60ConditionsHypertension, Vascular DiseasesArmsRemote Ischaemic Preconditioning, Sham Remote Ischaemic Preconditioning
NCT06021613 nacompletednot on this mapstarted 2024, after this paper: background citation

Marijuana and Acute Risk of Arrhythmia- Joint Abstinence and Exposure

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2025Enrolled108ConditionsPremature Atrial Contractions, Premature Ventricular ContractionsArmsRandomized instructions
NCT06495879 unknown statusnot on this mapstarted 2024, after this paper: background citation

Study of The Association Between Triglyceride Glucose Index and Severity of Coronary Artery Disease

TypeobservationalSponsorSohag UniversityRan2024 to 2025Enrolled100ConditionsCoronary Artery Disease
NCT06840132 nacompletednot on this map

The Effect of Ankle Foot Orthesis on Task-oriented Treatment in Stroke

TypeinterventionalSponsorAnkara Medipol UniversityRan2020 to 2024Enrolled39ConditionsStrokeArmsExercise
NCT06940544 narecruitingnot on this mapstarted 2023, after this paper: background citation

Uppsala Self-SCREENing of Heart Failure Study

TypeinterventionalSponsorUppsala UniversityRan2023 to 2026Enrolled500ConditionsHeart FailureArmsStepwise Multimodal Home-Based HF Screening
NCT07049211 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Individualized Closed-Loop Neuromodulation With Repetitive Transcranial Magnetic Stimulation Synchronized Task Training for Upper Limb Motor Dysfunction in Stroke Patients

TypeinterventionalSponsorRuijin HospitalRan2025 to 2028Enrolled51ConditionsUpper Extremity Dysfunction After the StrokeArmsIndividualized online stimulation, Non-individualized online stimulation, Sham stimulation
NCT07184541 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of a Nurse-led Daily Weight Monitoring Intervention (Wake and Weigh) on Heart Failure Quality of Life and Self-care

TypeinterventionalSponsorLee Anne SiegmundRan2024 to 2026Enrolled42ConditionsHeart FailureArmsWake and Weigh, Usual care
NCT07445932 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The PALL-VAD Study: Palliative Care Intervention to Improve Health Related Quality of Life for Patients With Heart Failure on Long-Term LVAD Support: A Pilot, Prospective, Randomized Trial

TypeinterventionalSponsorMedstar Health Research InstituteRan2026 to 2027Enrolled90ConditionsAdvanced Heart Failure, Mechanical Circulatory Support, Left Ventricular Assist Device, Palliative CareArmsPalliative care intervention
3 · Its place in the literature

Who cites it

3,024 citing papers in PubMed, 10 syntheses or guidelines pooled it, 5,571 citations in OpenAlex.

  1. Pooled it
  2. Combined transcranial direct current stimulation and mirror therapy for upper limb rehabilitation in patients with stroke: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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  11. Trial
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  18. Trajectory of longitudinal lending discrimination modifies the efficacy of a skills-based intervention in stroke survivors.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
    Trial
  19. Article
  20. Differences of plaque burden measures on CCTA in younger men and women.American journal of preventive cardiology · 2026
    Article

2,964 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Salim S Virani
Alvaro Alonso
Hugo J Aparicio
Emelia J Benjamin
Marcio S Bittencourt
Clifton W Callaway
April P Carson
Alanna M Chamberlain
Susan Cheng
Francesca N Delling
Mitchell S V Elkind
Kelly R Evenson
Jane F Ferguson
Deepak K Gupta
Sadiya S Khan
Brett M Kissela
Kristen L Knutson
Chong D Lee
Tené T Lewis
Junxiu Liu
Matthew Shane Loop
Pamela L Lutsey
Jun Ma
Jason Mackey
Seth S Martin
David B Matchar
Michael E Mussolino
Sankar D Navaneethan
Amanda Marma Perak
Gregory A Roth
Zainab Samad
Gary M Satou
Emily B Schroeder
Svati H Shah
Christina M Shay
Andrew Stokes
Lisa B VanWagner
Nae-Yuh Wang
Connie W Tsao
American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee

Funding

PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · BOSTON UNIVERSITY MEDICAL CAMPUS · 1985 to 2025
$8.2M
Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular DiseaseR01HL155717 · BETH ISRAEL DEACONESS MEDICAL CENTER · 2025 to 2025
$832k
NHLBI NIH HHS R01 HL155717NHLBI NIH HHS R03 HL145195NINDS NIH HHS L30 NS093634NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

backgroundThe American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).

methodsThe American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2021 Statistical Update is the product of a full year's worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year's edition includes data on the monitoring and benefits of cardiovascular health in the population, an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, the global burden of cardiovascular disease, and further evidence-based approaches to changing behaviors related to cardiovascular disease.

resultsEach of the 27 chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics.

conclusionsThe Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

Indexed as

American Heart AssociationBlood PressureCholesterolDiabetes MellitusDiet, HealthyExerciseGlobal Burden of DiseaseHealth BehaviorHeart DiseasesHospitalizationHumansObesityPrevalenceRisk FactorsSmokingStrokeCholesterolAHA Scientific Statementscardiovascular diseasesepidemiologyrisk factorsstatisticsstroke

Identifiers

PMID33501848
PMCPMC13036842
OpenAlexW3122226502

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 9 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.