ArticleInternational journal of environmental research and public health2021
The Obesity Paradox Predicts the Second Wave of COVID-19 to Be Severe in Western Countries.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- COVID-19, Anosmia, and Allergies: Is There a Relationship? A Pediatric Perspective.Journal of clinical medicine · 2022Article
- Obesity Impact on SARS-CoV-2 Infection: Pros and Cons "Obesity Paradox"-A Systematic Review.Journal of clinical medicine · 2022Review
- Review
- Computed tomography-defined body composition as prognostic markers for unfavourable outcomes and in-hospital mortality in coronavirus disease 2019.Journal of cachexia, sarcopenia and muscle · 2022Article
- Investigation on the Factors Associated with the Persistence of Anosmia and Ageusia in Saudi COVID-19 Patients.International journal of environmental research and public health · 2022Article
- Dysautonomia and Implications for Anosmia in Long COVID-19 Disease.Journal of clinical medicine · 2021Review
- Cross-National Variations in COVID-19 Mortality: The Role of Diet, Obesity and Depression.Diseases (Basel, Switzerland) · 2021Article
- Pandemic Leadership: Sex Differences and Their Evolutionary-Developmental Origins.Frontiers in psychology · 2021Review
- Acute kidney injury and COVID-19.The Egyptian journal of internal medicine · 2021Review
- Unrealistic Optimism and Risk for COVID-19 Disease.Frontiers in psychology · 2021Article
- Do Islanders Have a More Reactive Behavioral Immune System? Social Cognitions and Preferred Interpersonal Distances During the COVID-19 Pandemic.Frontiers in psychology · 2021Article
- COVID-19 Pandemic on Fire: Evolved Propensities for Nocturnal Activities as a Liability Against Epidemiological Control.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 5 countries.
Funding
Abstract
While COVID-19 infection and mortality rates are soaring in Western countries, Southeast Asian countries have successfully avoided the second wave of the SARS-CoV-2 pandemic despite high population density. We provide a biochemical hypothesis for the connection between low COVID-19 incidence, mortality rates, and high visceral adiposity in Southeast Asian populations. The SARS-CoV-2 virus uses angiotensin-converting enzyme 2 (ACE2) as a gateway into the human body. Although the highest expression levels of ACE2 are found in people's visceral adipose tissue in Southeast Asia, this does not necessarily make them vulnerable to COVID-19. Hypothetically, high levels of visceral adiposity cause systemic inflammation, thus decreasing the ACE2 amount on the surface of both visceral adipocytes and alveolar epithelial type 2 cells in the lungs. Extra weight gained during the pandemic is expected to increase visceral adipose tissue in Southeast Asians, further decreasing the ACE2 pool. In contrast, weight gain can increase local inflammation in fat depots in Western people, leading to worse COVID-related outcomes. Because of the biological mechanisms associated with fat accumulation, inflammation, and their differential expression in Southeast Asian and Western populations, the second wave of the pandemic may be more severe in Western countries, while Southeast Asians may benefit from their higher visceral fat depots.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.