ArticleScientific reports2021
Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Bibliometric Analysis on of the Impact of Screening to Minimize Maternal Mental Health on Neonatal Outcomes: A Systematic Review.Journal of clinical medicine · 2024Review
- The Potential Impact of the Gut Microbiota on Neonatal Brain Development and Adverse Health Outcomes.Children (Basel, Switzerland) · 2024Review
- Delivery by cesarean section leads to heavier adult bodyweight in prairie voles (Microtus ochrogaster).Hormones and behavior · 2024Article
- The inflammatory response to birth requires MyD88 and is driven by both mother and offspring.Brain, behavior, and immunity · 2024Article
- Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles.Hormones and behavior · 2023Article
- Post-partum depression: From clinical understanding to preclinical assessments.Frontiers in psychiatry · 2023Review
- Neonatal oxytocin gives the tempo of social and feeding behaviors.Frontiers in molecular neuroscience · 2022Review
- The Newborn's Reaction to Light as the Determinant of the Brain's Activation at Human Birth.Frontiers in integrative neuroscience · 2022Article
- Are there adverse outcomes for child health and development following caesarean section delivery? Can we justify using elective caesarean section to prevent obstetric pelvic floor damage?International urogynecology journal · 2021Review
- First Encounters: Effects of the Microbiota on Neonatal Brain Development.Frontiers in cellular neuroscience · 2021Review
- Vasopressin but Not Oxytocin Responds to Birth Stress in Infants.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2-3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.