Evidence map›Paper›PMID 33505536›Full record

ArticleDisease markers2021

Correlation between Serum Bone Turnover Markers and Estimated Glomerular Filtration Rate in Chinese Patients with Diabetes.

Xuming Zhu, Ying Zhou, Shanchao Hong, Yifeng Xue, Yubao Cui

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xuming ZhuDepartment of Clinical Laboratory, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu Province, China.ORCID https://orcid.org/0000-0002-4498-6794
Ying ZhouDepartment of Clinical Laboratory, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu Province, China.ORCID https://orcid.org/0000-0002-7009-5872
Shanchao HongDepartment of Clinical Laboratory, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu Province, China.ORCID https://orcid.org/0000-0003-1587-3253
Yifeng XueDepartment of Clinical Laboratory, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu Province, China.ORCID https://orcid.org/0000-0002-1016-0273
Yubao CuiDepartment of Clinical Laboratory, Wuxi People's Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu Province, China.ORCID https://orcid.org/0000-0001-7736-8012
Wuxi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDiabetes is a growing global public health concern with many significant disease complications. Multiple studies show that bone turnover markers (BTMs) are decreased in diabetes patients, indicating impaired bone metabolism in diabetes patients. A recent study also showed that in diabetes patients, BTMs are correlated with urine albumin to creatinine ratio, an indicator of nephropathy. However, whether BTMs are correlated with estimated glomerular filtration rate (eGFR) in diabetes remains unknown. This retrospective study accessed correlations between serum BTMs and eGFR in Chinese patients with diabetes and compare levels of BTMs and eGFR between diabetic patients and healthy individuals.

methodsThis study analyzed data from 221 diabetic patients (include type1 and type 2 diabetes) and 155 healthy individuals. Serum BTM levels and eGFR were compared between diabetic patients and healthy individuals. Pearson correlation analysis was used to assess correlations between BTMs and eGFR. Multiple logistic regression analysis adjusted for gender and age was performed to measure odd ratio (OR) and 95% confidence interval (95% CI) of BTMs on diabetes.

resultsPatients with diabetes had significant lower 25-hydroxyvitamin D (25(OH)D) levels (15.07 ± 6.20 ng/mL) than healthy group (17.89 ± 6.41 ng/mL) (

conclusionsIn the stage of diabetic nephropathy, bone turnover may accelerate. It is important to detect BTMs in the stage of diabetic nephropathy.

Indexed as

Glomerular Filtration RateAdultAgedAged, 80 and overBiomarkersCollagen Type IDiabetic NephropathiesFemaleHumansMaleMiddle AgedOsteocalcinPeptide FragmentsPeptidesProcollagenVitamin D25-hydroxyvitamin DBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptideOsteocalcinPeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptideVitamin D

Identifiers

PMID33505536
PMCPMC7806398
OpenAlexW3119390339

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.