Evidence map›Paper›PMID 33510583›Full record

ArticleMediators of inflammation2021

Activation of Opioid Receptors Attenuates Ischemia/Reperfusion Injury in Skeletal Muscle Induced by Tourniquet Placement.

Yue-Xian Guo, Gui-Ying Wang, Wen-Jie Cheng, Cai-Zhen Yan, Shuang Zhao, Zhao Li, Peng Liu, Xiu-Li Wang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05954689 (Femoral Artery Block for Reduction of Tourniquet Induced Hypertension), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05954689 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Femoral Artery Block for Reduction of Tourniquet Induced Hypertension: a Randomised Controlled Trial

TypeinterventionalSponsorHospital da Luz, PortugalRan2023 to 2024Enrolled50ConditionsTourniquets, Anesthesia, Conduction, Anesthetics, Local, HypertensionArmsFemoral artery block
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yue-Xian GuoDepartment of Surgery, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei 050051, China.
Gui-Ying WangDepartment of Surgery, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei 050051, China.
Wen-Jie ChengDepartment of Anesthesiology, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei 050051, China.
Cai-Zhen YanDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Shuang ZhaoDepartment of Anesthesiology, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei 050051, China.
Zhao LiDepartment of Anesthesiology, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei 050051, China.
Peng LiuDepartment of Anesthesiology, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei 050051, China.
Xiu-Li WangDepartment of Anesthesiology, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei 050051, China.ORCID https://orcid.org/0000-0002-4805-2569
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodMice were randomly assigned to the sham, I/R, Oxy, and I/R with Oxy groups. Oxy was injected intraperitoneally 30 min before tourniquet placement. Morphological changes of the gastrocnemius muscle in these mice were assessed by hematoxylin-eosin (HE) staining and electron microscopy. Expression levels of TLR4, NF-

resultsCompared with the I/R group, Oxy pretreatment attenuated skeletal muscle damage, decreased serum TNF-

conclusionTourniquet-induced acute limb I/R results in morphological and functional impairment in skeletal muscle. Pretreatment with Oxy attenuates skeletal muscle from acute I/R injury through inhibition of TLR4/NF-

Indexed as

Muscle ContractionTourniquetsAdenosine TriphosphateAnimalsInflammationMaleMiceMice, Inbred C57BLMicroscopy, ElectronMuscle, SkeletalNF-kappa B p50 SubunitPerfusionPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReceptors, OpioidReperfusion InjurySirtuin 1Adenosine TriphosphateNF-kappa B p50 SubunitNfkb1 protein, mousePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReceptors, OpioidSirt1 protein, mouseSirtuin 1Tlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID33510583
PMCPMC7822682
OpenAlexW3119298530

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.