Evidence map›Paper›PMID 33511375›Full record

ArticleMed (New York, N.Y.)2021

Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive

Jianbo Zhang, Yu-Ja Huang, Jun Young Yoon, John Kemmitt, Charles Wright, Kirsten Schneider, Pierre Sphabmixay, Victor Hernandez-Gordillo, Steven J Holcomb, Brij Bhushan and 12 more

Open access · bronzeAbstract read
In one paragraph

Article in Med (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 124 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. mGem:mBio · 2026
    Article
  8. Frontiers in immunology · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Jianbo ZhangDepartment of Biological Engineering.
Yu-Ja HuangDepartment of Biological Engineering.
Jun Young YoonDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
John KemmittDepartment of Biological Engineering.
Charles WrightDepartment of Biological Engineering.
Kirsten SchneiderDepartment of Biological Engineering.
Pierre SphabmixayDepartment of Biological Engineering.
Victor Hernandez-GordilloDepartment of Biological Engineering.
Steven J HolcombDepartment of Biological Engineering.
Brij BhushanDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gar RohatgiEPAM Continuum, 41 University Drive, Newtown, PA 18940, USA.
Kyle BentonEPAM Continuum, 41 University Drive, Newtown, PA 18940, USA.
David CarpenterEPAM Continuum, 41 University Drive, Newtown, PA 18940, USA.
Jemila C KesterDepartment of Biological Engineering.
George EngDepartment of Biological Engineering.
David T BreaultDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Omer YilmazDepartment of Biological Engineering.
Mao TaketaniDepartment of Biological Engineering.
Christopher A VoigtDepartment of Biological Engineering.
Rebecca L CarrierDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
David L TrumperDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Linda G GriffithDepartment of Biological Engineering.
Massachusetts Institute of Technology · USHarvard University · USNortheastern University · USYonsei University · KR

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
MOLECULAR IMMUNOLOGY AND TUMOR BIOLOGYT32CA009216 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Michael Langenau · 1985 to 2026
$10.6M
GuMI: New In Vitro Platforms to Parse the Human Gut Epithelial-Microbiome-Immune AxisR01EB021908 · NIBIB · NORTHEASTERN UNIVERSITY · PI CARRIER, REBECCA L, GRIFFITH, LINDA G · 2016 to 2020
$5.2M
Regulation of the Intestinal Stem Cells During RegenerationR01DK119488 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI BREAULT, DAVID T · 2019 to 2022
$1.9M
NCI NIH HHS T32 CA009216NIBIB NIH HHS R01 EB021908NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK119488NIEHS NIH HHS P30 ES002109
6 · The paper itself

Abstract

backgroundThe gut microbiome plays an important role in human health and disease. Gnotobiotic animal and

methodsHere, we investigated the effects of an abundant super oxygen-sensitive commensal anaerobe,

findingsLong-term continuous co-culture of

conclusionsOur results are consistent with some clinical observations regarding

Indexed as

Faecalibacterium prausnitziiOxygenAnimalsAnti-Inflammatory AgentsButyratesColonHumansAnti-Inflammatory AgentsButyratesOxygen

Identifiers

PMID33511375
PMCPMC7839961
OpenAlexW3047172990

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.