Evidence map›Paper›PMID 33511728›Full record

ReviewJournal of cachexia, sarcopenia and muscle2021

Effects of statins on mitochondrial pathways.

Hamid Mollazadeh, Erfan Tavana, Giovanni Fanni, Simona Bo, Maciej Banach, Matteo Pirro, Stephan von Haehling, Tannaz Jamialahmadi, Amirhossein Sahebkar

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 14 pooled it
32.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 14 syntheses or guidelines pooled it, 229 citations in OpenAlex.

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  15. Drug safety in patients with mitochondrial disease: an observational cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Observational
  16. Review
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  20. Prevalence and treatment of mitochondrial diabetes in Southwest Finland.Journal of diabetes and metabolic disorders · 2026
    Article

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Hamid MollazadehDepartment of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.ORCID 0000-0002-8157-5732
Erfan TavanaStudent Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Giovanni FanniDepartment of Medical Sciences, University of Turin, Turin, Italy.
Simona BoDepartment of Medical Sciences, AOU Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
Maciej BanachDepartment of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland.ORCID 0000-0001-6690-6874
Matteo PirroUnit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy.
Stephan von HaehlingDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.
Tannaz JamialahmadiDepartment of Food Science and Technology, Islamic Azad University, Quchan, Quchan, Iran.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-8656-1444
North Khorasan University of Medical Sciences · IRUniversity of Turin · ITAtomic Energy Organization of Iran · IRMashhad University of Medical Sciences · IRMedical University of Lodz · PLUniversitätsmedizin Göttingen · DEUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins are a family of drugs that are used for treating hyperlipidaemia with a recognized capacity to prevent cardiovascular disease events. They inhibit β-hydroxy β-methylglutaryl-coenzyme A reductase, i.e. the rate-limiting enzyme in mevalonate pathway, reduce endogenous cholesterol synthesis, and increase low-density lipoprotein clearance by promoting low-density lipoprotein receptor expression mainly in the hepatocytes. Statins have pleiotropic effects including stabilization of atherosclerotic plaques, immunomodulation, anti-inflammatory properties, improvement of endothelial function, antioxidant, and anti-thrombotic action. Despite all beneficial effects, statins may elicit adverse reactions such as myopathy. Studies have shown that mitochondria play an important role in statin-induced myopathies. In this review, we aim to report the mechanisms of action of statins on mitochondrial function. Results have shown that statins have several effects on mitochondria including reduction of coenzyme Q10 level, inhibition of respiratory chain complexes, induction of mitochondrial apoptosis, dysregulation of Ca

Indexed as

MitochondriaHumansHydroxymethylglutaryl-CoA Reductase InhibitorsOxidative PhosphorylationOxidative StressHydroxymethylglutaryl-CoA Reductase InhibitorsApoptosisCoenzyme Q10Cognitive impairmentDiabetesMitochondriaMyopathyRespiratory chainSAMSStatin

Identifiers

PMID33511728
PMCPMC8061391
OpenAlexW3125158701

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.