Evidence map›Paper›PMID 33513852›Full record

ArticleInternational journal of molecular sciences2021

Sara Pelucchi, Giulia Ravasi, Cristina Arosio, Mario Mauri, Rocco Piazza, Raffaella Mariani, Alberto Piperno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Relationship of Genetic Variability (Health science reports · 2026
    Article
  3. Article
  4. Review
  5. Idiopathic erythrocytosis: a germline disease?Clinical and experimental medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara PelucchiDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Giulia RavasiDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Cristina ArosioLiceo Artistico Statale Amedeo Modigliani, 20833 Giussano, Italy.
Mario MauriDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-5876-6215
Rocco PiazzaDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-4198-9620
Raffaella MarianiCentre of European Reference Network (EuroBloodNet) and Centre for Rare Diseases-Disorders of Iron Metabolism-ASST-Monza, San Gerardo Hospital Monza, 20900 Monza, Italy.
Alberto PipernoDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HFE-related hereditary hemochromatosis (HH) is characterized by marked phenotypic heterogeneity. Homozygosity for p.C282Y is a low penetrance genotype suggesting that the HFE-HH is a multifactorial disease resulting from a complex interaction involving a major gene defect, genetic background and environmental factors. We performed a targeted NGS-based gene panel to identify new candidate modifiers by using an extreme phenotype sampling study based on serum ferritin and iron removed/age ratio. We found an increased prevalence of the

Indexed as

Genetic Predisposition to Diseasealpha 1-AntitrypsinFerritinsFurinGenotypeHeme Oxygenase-1HemochromatosisHemochromatosis ProteinHepcidinsHigh-Throughput Nucleotide SequencingHumansHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsMutationSerine EndopeptidasesVascular Endothelial Growth Factor Aalpha 1-AntitrypsinFerritinsFurinFURIN protein, humanHAMP protein, humanHeme Oxygenase-1Hemochromatosis ProteinHepcidinsHFE protein, humanHIF1A protein, humanHMOX1 protein, humanHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsSerine EndopeptidasesSERPINA1 protein, humanTMPRSS6 protein, humanVascular Endothelial Growth Factor AVEGFA protein, humanhereditary hemochromatosisHFEHIF1Amodifiers

Identifiers

PMID33513852
PMCPMC7865586

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.