Evidence map›Paper›PMID 33513983›Full record

ArticleGenes2021

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats.

Jianfang Wang, Jie Sui, Chao Mao, Xiaorui Li, Xingyi Chen, Chengcheng Liang, Xiaohui Wang, Si-Hu Wang, Cunling Jia

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 63 citations in OpenAlex.

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  8. Genome-wide selective sweep analysis in high-altitude Changthangi goats reveals candidate genes for pashmina fiber production.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
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  11. Deciphering the molecular drivers for cashmere/pashmina fiber production in goats: a comprehensive review.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jianfang WangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Jie SuiCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Chao MaoCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Xiaorui LiCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Xingyi ChenCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0000-0001-9337-7437
Chengcheng LiangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.ORCID 0000-0002-6188-2911
Xiaohui WangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Si-Hu WangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Cunling JiaCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Northwest A&F University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for cashmere goat with double-coat, the periodic change may be due to other regulatory molecules and signal pathways. To understand the mechanism of periodic development of hair follicle, we performed a weighted gene coexpression network analysis (WGCNA) to mine key genes and establish an interaction network by utilizing the NCBI public dataset. Ten coexpression modules, including 7689 protein-coding genes, were constructed by WGCNA, six of which are considered to be significantly related to the development of the hair follicle cycle. A functional enrichment analysis for each model showed that they are closely related to ECM- receptor interaction, focal adhesion, PI3K-Akt signaling pathway, estrogen signaling pathway, and so on. Combined with the analysis of differential expressed genes, 12 hub genes from coexpression modules were selected as candidate markers, i.e.,

Indexed as

Gene Expression RegulationSignal TransductionAnimalsComputational BiologyDatabases, GeneticGene Expression ProfilingGene Regulatory NetworksGoatsHair FollicleOrganogenesisTranscriptomecoexpression networkhair follicle cyclehub genesWGCNA

Identifiers

PMID33513983
PMCPMC7911279
OpenAlexW3121694035

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.