Metformin × cardiovascular events

SynthesisCardiovascular diabetology2021

Association of metformin monotherapy or combined therapy with cardiovascular risks in patients with type 2 diabetes mellitus.

Tian Li et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 2021

Range includes no effect

No clear effect on deaths

−2%−31% to +38%

Bigger than 1 in 10 for all-cause mortality

As reported

RR 0.98, 95% CI 0.69–1.38 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on cardiovascular events

1.1×0.6× to 2.1×

Bigger than 2 in 10 for cardiovascular events

As reported

RR 1.13, 95% CI 0.60–2.15

Range includes no effect

No clear effect on cardiovascular events

−13%−30% to +7%

Bigger than 2 in 10 for cardiovascular events

As reported

RR 0.87, 95% CI 0.70–1.07

Range includes no effect

No clear effect on cardiovascular events

+2%−39% to +71%

Smaller than almost all for cardiovascular events

As reported

RR 1.02, 95% CI 0.61–1.71

+3 more in the walkthrough ↓

Seven numbers in the abstract

the abstract, start to end

lower risk of all-cause mortality (RR: 0.98; 95%CI: 0.69-1.38; P = 0.90), cardiovascular mortality (RR: 1.13; 95% CI: 0.60, 2.15; P = 0.70), macrovascular events (RR: 0.87; 95%CI: 0.70-1.07; P = 0.19), heart failure (RR: 1.02; 95% CI:0.61-1.71; P = 0.95), and microvascular events (RR: 0.78; 95% CI:0.54-1.13; P = 0.19).

higher risk of all-cause mortality (RR: 1.49; 95% CI: 1.02, 2.16) and cardiovascular mortality (RR: 2.21; 95% CI: 1.22, 4.00) compared

← favours treatmentfavours comparator →
could be chance
All-cause mortality
RR 0.980.69–1.38
Cardiovascular events
RR 1.130.60–2.15
Cardiovascular events
RR 0.870.70–1.07
Cardiovascular events
RR 1.020.61–1.71
Cardiovascular events
RR 0.780.54–1.13
All-cause mortality
RR 1.491.02–2.16
Cardiovascular events
RR 2.211.22–4.00
MetforminCardiovascular eventsAll-cause mortality

Metformin × cardiovascular eventshelps?mixed

unlikelylikely
0.50not counted

Metformin × all-cause mortalityhelps?one trial

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 33516224