Evidence map›Paper›PMID 33517841›Full record

ArticleSmall GTPases2022

Investigating increased hematopoietic stem cell fitness in a novel mouse model.

Laila Karra, Jeroen P Roose

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small GTPases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Laila KarraORCID 0000-0001-5503-2809
Jeroen P RooseDepartment of Anatomy, University of California, San Francisco, San Francisco, California USA.ORCID 0000-0003-4746-2811
Twitter (United States) · USUniversity of California, San Francisco · US

Funding

Balanced signaling cues to guide cell transitions in the blood lineage continuumR01HL120724 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAKRABORTY, ARUP K., NOLAN, GARRY P · 2015 to 2019
$3.7M
Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependenceR01CA187318 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEROEN ROOSE · 2015 to 2026
$3.6M
NCI NIH HHS R01 CA187318NHLBI NIH HHS R01 HL120724
6 · The paper itself

Abstract

T-cell acute lymphoblastic leukaemia (T-ALL) is a bone marrow (BM) malignancy affecting children and adults. Typically treated with chemotherapy, leukaemia remains a major death cause in people under 20 years old. Understanding molecularly altered pathways in T-ALL may lead to new therapeutic avenues in the future. Ras pathway dysregulation is common in T-ALL. We have shown elevated expression levels of the Ras guanine nucleotide exchange factor RasGRP1 in T-ALL patients, which results in constant production of active Ras (RasGTP). When leukaemia cell lines are exposed to cytokines, RasGTP levels further increase in a RasGRP1-dependent manner. How overexpressed RasGRP1 may impact primary BM cells has remained unknown. We recently published a new

Indexed as

Precursor T-Cell Lymphoblastic Leukemia-LymphomaAnimalsCytokinesDisease Models, AnimalGuanine Nucleotide Exchange FactorsHematopoietic Stem CellsMiceCytokinesGuanine Nucleotide Exchange FactorsRasgrp1 protein, mouseCancerHematopoiesisleukaemiametabolismmouse modelsmTORpi3kRasrasgrp1stem cells

Identifiers

PMID33517841
PMCPMC9707538
OpenAlexW3128761827

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.