Evidence mapPaperPMID 33519456Full record

ArticleFrontiers in pharmacology2020

Physiologically-Based Pharmacokinetic-Pharmacodynamics Model Characterizing CYP2C19 Polymorphisms to Predict Clopidogrel Pharmacokinetics and Its Anti-Platelet Aggregation Effect Following Oral Administration to Coronary Artery Disease Patients With or Without Diabetes.

Ru-Jun Xu, Wei-Min Kong, Xiao-Fei An, Jian-Jun Zou, Li Liu, Xiao-Dong Liu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ru-Jun XuCenter of Pharmacokinetics and Metabolism, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
Wei-Min KongCenter of Pharmacokinetics and Metabolism, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
Xiao-Fei AnDepartment of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinse Medicine, Nanjing, China.
Jian-Jun ZouDepartment of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Li LiuCenter of Pharmacokinetics and Metabolism, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
Xiao-Dong LiuCenter of Pharmacokinetics and Metabolism, College of Pharmacy, China Pharmaceutical University, Nanjing, China.
China Pharmaceutical University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

carboxylesterase 1 activityclopidogrelcoronary artery diseaseCYP2C19 polymorphismdiabetes mellitusPBPK-PD model

Identifiers

PMID33519456
PMCPMC7845657
OpenAlexW3111721155

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.