ArticleWorld journal of diabetes2021
Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience.
Article in World journal of diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prevalence of autoimmune comorbidities and association with glycemic control by CGM-derived parameters in type 1 diabetes.Endocrine · 2025Article
- Knowledge and Performance of Iranian Internists Regarding Dyslipidemia According to Lipid Guidelines and Their Relationships with Personal and Occupational Characteristics.The journal of Tehran Heart Center · 2024Article
- Impact of statin treatment on cardiovascular risk in patients with type 1 diabetes: a population-based cohort study.Journal of translational medicine · 2023Article
- Sex differences in body composition in youth with type 1 diabetes and its predictive value in cardiovascular disease risk assessment.Diabetes/metabolism research and reviews · 2023Observational
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Authors and funding
10 authors.
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Abstract
backgroundType 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis.
aimTo examine risk factors for dyslipidemia in young subjects with T1D.
methodsLongitudinal and cross-sectional retrospective study of 170 young subjects with T1D (86 males; baseline mean age 12.2 ± 5.6 years and hemoglobin A1c 8.4% ± 1.4%) were followed in a single tertiary diabetes center for a median duration of 15 years. Predictors for outcomes of lipid profiles at last visit (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein-cholesterol [LDL-c], and high-density lipoprotein-cholesterol [HDL-c]) were analyzed by stepwise linear regression models.
resultsAt baseline, 79.5% of the patients had at least one additional CVD risk factor (borderline dyslipidemia/dyslipidemia [37.5%], pre-hypertension/hypertension [27.6%], and overweight/obesity [16.5%]) and 41.6% had multiple (≥ 2) CVD risk factors. A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1% of the cohort. Predictors of elevated TC: family history of CVD (β[SE] = 23.1[8.3],
conclusionOur findings suggest that elevated lipid profiles are associated with DBP and a positive family history of CVD. It is of utmost importance to prevent and control modifiable risk factors such as these, as early as childhood, given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia.
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